Tracking the order of warning symptoms before migraine attacks
Follows adults with migraine to study which warning signs appear first before attacks.
Plain-language title generated from the registry record
Registry title: Chronology and Sequence of Premonitory Symptoms
Key facts
- Where
- Latina, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07681466, who can take part
Where in Italy
- Sapienza University of Rome, Polo Pontino, centro cefalee, ICOTLatina, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Roma La Sapienza
- Trial code
- NCT07681466
- Record updated
- 2 July 2026
- Original description
The purpose of this study is to prospectively investigate the temporal sequence of premonitory symptoms across multiple migraine attacks.Read full original descriptionShow less
Chronology and Sequence of Premonitory Symptoms to Understand How Migraine Attack Starts: the CHRONOpS Study
The purpose of this study is to prospectively investigate the temporal sequence of premonitory symptoms across multiple migraine attacks.
Inclusion: Diagnosis of episodic (EM) or chronic migraine (CM) or CM with medication overuse headache (MOH) according to ICHD-III criteria; Age between 18 and 65 years; At least 2 migraine days (MMD) in the month preceding the inclusion; Migraine history of at least 12 months prior to inclusion; Signed written informed consent.
Exclusion: History of migraine for < 12 months prior to the inclusion; History or current diagnosis of secondary headache disorders as defined by ICHD-III; History of other neurological comorbidities or major psychiatric disorders; Opioid overuse according to the ICHD-III criteria; Pregnancy or breastfeeding.