Tracking the order of warning symptoms before migraine attacks
Follows adults with migraine to study which warning signs appear first before attacks.
Key facts
- Who runs it
- University of Roma La Sapienza
- Where
- Latina, ItalySee the site
- Trial code
- Registry title
- Chronology and Sequence of Premonitory Symptoms
- Status
- Recruiting
- People taking part
- 500 people, planned
- Started
- 17 Mar 2026
- Expected to end
- Sept 2027
- Type of study
- Observational
- Record updated
- 2 July 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with episodic or chronic migraine, to study the order in which early warning symptoms appear before migraine attacks.
- Age
- 18 to 65 years
- Sex
- All sexes can join
- Disease stage
- Episodic migraine, chronic migraine, or chronic migraine with medication overuse headache, diagnosed by ICHD-III criteria. At least 2 migraine days in the month before joining. Migraine for at least 12 months.
Main reasons for not taking part
- Headache caused by another illness (secondary headache disorder), now or in the past
- Other nerve (neurological) diseases or major mental health disorders in the past
- Migraine for less than 12 months
- Overuse of opioid medicines
- Pregnancy or breastfeeding
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Diagnosis of episodic (EM) or chronic migraine (CM) or CM with medication overuse headache (MOH) according to ICHD-III criteria
- Age between 18 and 65 years
- At least 2 migraine days (MMD) in the month preceding the inclusion
- Migraine history of at least 12 months prior to inclusion
- Signed written informed consent
Who cannot take part
- History of migraine for < 12 months prior to the inclusion
- History or current diagnosis of secondary headache disorders as defined by ICHD-III
- History of other neurological comorbidities or major psychiatric disorders
- Opioid overuse according to the ICHD-III criteria
- Pregnancy or breastfeeding
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Where in Italy
- Sapienza University of Rome, Polo Pontino, centro cefalee, ICOTLatina, ItalyContact: Gabriele Sebastianelli, MDTaking people
About the trial
What the trial wants to find out
The purpose of this study is to prospectively investigate the temporal sequence of premonitory symptoms across multiple migraine attacks.
The group in the trial
- patients with migraine
episodic migraine or chronic migraine or migraine with aura
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Chronology and Sequence of Premonitory Symptoms to Understand How Migraine Attack Starts: the CHRONOpS Study
- Plain-language title
- Tracking the order of warning symptoms before migraine attacksGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07681466, who can take part
- Record updated
- 2 July 2026