Online Versus In-Person Rehabilitation for Adults With Hemophilia and Chronic Pain
Compares home-based online rehabilitation with in-person rehabilitation in adults with hemophilia and chronic pain.
Plain-language title generated from the registry record
Registry title: Multimodal Telerehabilitation Versus Face-to-Face Care for Adults With Hemophilia and Chronic Pain
Key facts
- Where
- Santiago, ChileSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for men with hemophilia A or B and long-lasting pain in the elbow, knee or ankle. It compares a 6-week online rehabilitation program with the same program in person.
- Age
- 18 to 60 years
- Sex
- Men only
- Disease stage
- Hemophilia A or hemophilia B, with chronic pain: pain every day for at least 3 months, or on at least half of the days in the previous 6 months. The pain involves the elbow, knee or ankle.
- Earlier treatment
- People must be receiving prophylactic clotting factor replacement therapy at least three times per week. They must have a current medical referral for physical therapy. They must not have taken part in a pain neuroscience education program before.
Main reasons for not taking part
- Cannot understand the study instructions or give written informed consent
- Neurological disorder affecting the central nervous system (for example, stroke)
- Currently using alternative therapies for pain
- Orthopedic surgery or major musculoskeletal injury in the previous 12 months
- Does not live in the Metropolitan Region of Chile
Read by machine on 13 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT07682519, who can take part
Where in Chile
- Department of Physical Therapy, Faculty of Medicine, University of ChileSantiago, ChileContact: Rodrigo Núñez-Cortés, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Chile
- Trial code
- NCT07682519
- Record updated
- 7 July 2026
- Original description
Hemophilia is an inherited bleeding disorder that is commonly associated with chronic joint pain, reduced physical function, and decreased quality of life. Pain science education combined with exercise therapy has shown beneficial effects in people with chronic musculoskeletal pain; however, its effectiveness in people with hemophilia remains largely unknown. Telerehabilitation may improve access to rehabilitation by reducing geographical and transportation barriers, but its effectiveness compared with face-to-face delivery has not been established in this population.Read full original descriptionShow less
Effects of a Multimodal Telerehabilitation Intervention Versus Face-to-Face Care in Adults With Hemophilia and Chronic Pain: A Randomized Controlled Non-Inferiority Trial
Hemophilia is an inherited bleeding disorder that is commonly associated with chronic joint pain, reduced physical function, and decreased quality of life. Pain science education combined with exercise therapy has shown beneficial effects in people with chronic musculoskeletal pain; however, its effectiveness in people with hemophilia remains largely unknown. Telerehabilitation may improve access to rehabilitation by reducing geographical and transportation barriers, but its effectiveness compared with face-to-face delivery has not been established in this population.
This randomized controlled non-inferiority trial will compare a 6-week multimodal telerehabilitation program consisting of pain science education and therapeutic exercise with an equivalent face-to-face program in adults with hemophilia and chronic pain. Participants will be randomly assigned to one of the two interventions. Clinical outcomes will be assessed before and after the intervention by an assessor blinded to group allocation. The study aims to determine whether telerehabilitation provides clinical outcomes that are not inferior to those achieved with conventional face-to-face rehabilitation.
Inclusion: Male adults aged 18 to 60 years. Diagnosis of hemophilia A or hemophilia B. Chronic pain, defined as pain occurring every day for at least 3 months or on at least half of the days during the previous 6 months; Pain involving the elbow, knee, or ankle. Receiving prophylactic clotting factor replacement therapy at least three times per week; Current medical referral for physical therapy. Residence in the Metropolitan Region of Chile. Ability to understand study procedures and provide written informed consent.
Exclusion: Inability to understand study instructions or provide written informed consent. Neurological disorders affecting the central nervous system (e.g., stroke). Current participation in alternative therapies for pain management. Previous participation in a pain neuroscience education program. Orthopedic surgery or major musculoskeletal trauma within the previous 12 months.