Spinal Cord Stimulation Plus Brain-Computer Interface Training for Arm Weakness After Stroke
Tests spinal cord stimulation with brain-computer training for arm weakness after stroke.
Plain-language title generated from the registry record
Registry title: Spinal Cord Stimulation Combined With Motor Imagery Brain-Computer Interface for Chronic Post-Stroke Upper Limb Motor Dysfunction
Key facts
- Where
- Hangzhou, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who had one stroke more than 6 months ago and still have moderate weakness in one arm. It tests spinal cord stimulation together with brain-computer interface arm training.
- Age
- 18 to 75 years
- Sex
- All sexes can join.
- Disease stage
- First-ever stroke on one side of the brain (blocked or bleeding), confirmed by CT or MRI, with weakness on one side of the body. At least 6 months have passed since the stroke. The arm score (Fugl-Meyer) is between 10 and 40 and has changed less than 10% in the last month.
- Earlier treatment
- No earlier nerve-stimulation surgery for one-sided weakness, such as spinal cord stimulation or deep brain stimulation.
- Biomarker or test result
- At least one active movement in the wrist or fingers of the weak arm, with muscle strength of grade 1 or higher. Mini-Mental State Examination score of 24 or higher.
Main reasons for not taking part
- Other nerve diseases that can cause movement problems, such as Parkinson's disease, multiple sclerosis or spinal cord injury
- Severe vision or hearing problems that block use of the training system
- Reasons the spinal cord stimulation surgery is unsafe, such as severe bleeding problems, infection at the puncture site, severe spine deformity or spinal canal stenosis
- History of epilepsy, metal implants in the skull, a pacemaker, or other reasons MRI is unsafe
- Pregnancy or breastfeeding
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07686822, who can take part
Where in China
- Zhejiang Provincial People's HospitalHangzhou, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Zhejiang Provincial People's Hospital
- Trial code
- NCT07686822
- Record updated
- 7 July 2026
- Original description
This clinical study aims to evaluate the efficacy and safety of spinal cord stimulation combined with non-invasive motor imagery brain-computer interface rehabilitation training in patients with upper limb motor dysfunction after chronic stroke. The study includes an experimental group receiving spinal cord stimulation combined with motor imagery brain-computer interface rehabilitation training and a control group receiving motor imagery brain-computer interface rehabilitation training alone. The primary outcome is upper limb motor function assessed by the Fugl-Meyer Assessment for Upper Extremity. Secondary outcomes include muscle tone, upper limb functional activity, activities of daily living, adverse events, serious adverse events, and exploratory neurophysiological and neuroimaging indicators.Read full original descriptionShow less
A Prospective, Single-Center, Non-Randomized, Parallel-Controlled Study to Evaluate the Efficacy and Safety of Spinal Cord Stimulation Combined With Non-Invasive Motor Imagery Brain-Computer Interface Rehabilitation Training for Upper Limb Motor Dysfunction in Patients With Chronic Stroke
This clinical study aims to evaluate the efficacy and safety of spinal cord stimulation combined with non-invasive motor imagery brain-computer interface rehabilitation training in patients with upper limb motor dysfunction after chronic stroke. The study includes an experimental group receiving spinal cord stimulation combined with motor imagery brain-computer interface rehabilitation training and a control group receiving motor imagery brain-computer interface rehabilitation training alone. The primary outcome is upper limb motor function assessed by the Fugl-Meyer Assessment for Upper Extremity. Secondary outcomes include muscle tone, upper limb functional activity, activities of daily living, adverse events, serious adverse events, and exploratory neurophysiological and neuroimaging indicators.
Inclusion: Age 18 to 75 years; First-ever unilateral supratentorial stroke, either ischemic or hemorrhagic, confirmed by computed tomography or magnetic resonance imaging, resulting in hemiparesis, with disease duration longer than 6 months; At least one active movement in the wrist or fingers of the affected upper limb, with muscle strength of grade 1 or higher; Fugl-Meyer Assessment for Upper Extremity score between 10 and 40, indicating moderate upper limb motor impairment; Change in Fugl-Meyer Assessment score less than 10% within the previous month, indicating a functional plateau; Clear consciousness and basically normal cognitive function, with Mini-Mental State Examination score of 24 or higher; Stable clinical condition and ability to understand and cooperate with simple instructions and rehabilitation training; Written informed consent voluntarily signed by the participant or legal guardian.
Exclusion: Previous neuromodulation surgery for hemiparesis, such as spinal cord stimulation or deep brain stimulation; Other neurological diseases that may cause motor dysfunction, such as Parkinson's disease, multiple sclerosis, or spinal cord injury; Severe visual or auditory impairment that prevents cooperation with visual or auditory feedback instructions of the brain-computer interface system; Contraindications to spinal cord stimulation surgery, such as severe coagulation dysfunction, infection at the puncture site, severe spinal deformity, or spinal canal stenosis; History of epilepsy, intracranial metal implants, cardiac pacemaker, or other contraindications to magnetic resonance imaging; Any other condition judged by the investigator to make the participant unsuitable for this study; Pregnancy or lactation.