Personalized high-intensity interval exercise for heart failure with preserved ejection fraction

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 35 to 70 with stable heart failure with preserved ejection fraction (HFpEF) who do little exercise. It tests a personalised high-intensity interval training programme.

Age

35 to 70 years

Sex

Men and women

Disease stage

HFpEF at Stage 4 of CKM syndrome, clinically stable in the past month, NYHA class II-III

Main reasons for not taking part

• Reasons that make a cardiopulmonary exercise test unsafe
• Positive finding on the exercise ECG during the test
• Psychiatric disorder
• Movement disorder or leg exercise-related injury in the past 6 months
• Pregnant, breastfeeding, or planning pregnancy soon

The registry criteria, word for word

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

• Are you between 35 and 70 years old?YesNo

What the trial wants to find out

Cardiovascular-Kidney-Metabolic (CKM) Syndrome is a continuous clinical disease spectrum integrating cardiovascular, renal, and metabolic disorders. Heart failure with preserved ejection fraction (HFpEF) is considered Stage 4 of CKM syndrome, characterized primarily by impairment of cardiac structure and function. Numerous studies have confirmed that exercise intervention is effective in improving metabolic profiles and inflammatory status in Stages 0-3 of CKM syndrome (e.g., obesity, metabolic syndrome, hypertension, and diabetes), and significantly improves clinical outcomes. However, for Stage 4 CKM syndrome, especially in patients with HFpEF, conventional exercise prescription faces significant challenges in balancing safety and efficacy. Moreover, traditional "one-size-fits-all" exercise rehabilitation strategies have failed to significantly improve clinical outcomes due to the lack of individualized precision approaches.

The 2 groups in the trial

• HIIT intervention groupTreatment being tested

  Subjects in the intervention group will undergo a 24-week personalized high-intensity interval training (HIIT) program, four times per week, with the exercise protocol tailored based on cardiopulmonary exercise testing (CPET). In addition, they will receive guideline-directed healthy lifestyle recommendations and optimal medical therapy (GDMT)

  Treatment: High-intensity interval training

• Standard care control groupNo study treatment, for comparison

  Control group subjects will receive guideline-directed optimal medical therapy (GDMT) , identical to that provided to the intervention group. In addition, they will receive a single, standardized health education session focused on HFpEF and obesity management, covering general recommendations regarding diet, weight management, and regular physical activity. No structured or supervised exercise prescription or program will be offered to the control group.