Personalized high-intensity interval exercise for heart failure with preserved ejection fraction
Tests personalized interval exercise in people with heart failure with preserved ejection fraction.
Plain-language title generated from the registry record
Registry title: Cardiopulmonary Exercise Testing-based High-intensity Interval Training For Improving Heart Failure With Preserved Ejection Fraction
Key facts
- Where
- Beijing, Qingdao, Shanghai, and Wuhan, ChinaSee the 13 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 35 and 70 years old?
Source: NCT07693049, who can take part
Where in China
- Beijing Chao-Yang Hospital, Capital Medical UniversityBeijing, ChinaNot yet recruiting
- Beijing HospitalBeijing, ChinaNot yet recruiting
- Beijing Xiaotangshan HospitalBeijing, ChinaNot yet recruiting
- Beijing Zhongguancun HospitalBeijing, ChinaNot yet recruiting
- Community Health Station of the Party School of the Central Committee of C.P.CBeijing, ChinaNot yet recruiting
- Jimenli Community Health Service CenterBeijing, ChinaNot yet recruiting
- Peking University First HospitalBeijing, ChinaNot yet recruiting
- Peking University People's HospitalBeijing, ChinaNot yet recruiting
- Peking University Third HospitalBeijing, ChinaTaking people
- Xueyuanlu Community Health Service CenterBeijing, ChinaNot yet recruiting
- QingDao Municipal HospitalQingdao, ChinaNot yet recruiting
- Shanghai East HospitalShanghai, ChinaNot yet recruiting
- Wuhan Asia Heart HospitalWuhan, ChinaNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Peking University Third Hospital
- Trial code
- NCT07693049
- Record updated
- 21 October 2026
- Original description
Cardiovascular-Kidney-Metabolic (CKM) Syndrome is a continuous clinical disease spectrum integrating cardiovascular, renal, and metabolic disorders. Heart failure with preserved ejection fraction (HFpEF) is considered Stage 4 of CKM syndrome, characterized primarily by impairment of cardiac structure and function. Numerous studies have confirmed that exercise intervention is effective in improving metabolic profiles and inflammatory status in Stages 0-3 of CKM syndrome (e.g., obesity, metabolic syndrome, hypertension, and diabetes), and significantly improves clinical outcomes. However, for Stage 4 CKM syndrome, especially in patients with HFpEF, conventional exercise prescription faces significant challenges in balancing safety and efficacy. Moreover, traditional "one-size-fits-all" exercise rehabilitation strategies have failed to significantly improve clinical outcomes due to the lack of individualized precision approaches.Read full original descriptionShow less
Cardiopulmonary Exercise Testing-based High-intensity Interval Training For Improving Heart Failure With Preserved Ejection Fraction
Cardiovascular-Kidney-Metabolic (CKM) Syndrome is a continuous clinical disease spectrum integrating cardiovascular, renal, and metabolic disorders. Heart failure with preserved ejection fraction (HFpEF) is considered Stage 4 of CKM syndrome, characterized primarily by impairment of cardiac structure and function. Numerous studies have confirmed that exercise intervention is effective in improving metabolic profiles and inflammatory status in Stages 0-3 of CKM syndrome (e.g., obesity, metabolic syndrome, hypertension, and diabetes), and significantly improves clinical outcomes. However, for Stage 4 CKM syndrome, especially in patients with HFpEF, conventional exercise prescription faces significant challenges in balancing safety and efficacy. Moreover, traditional "one-size-fits-all" exercise rehabilitation strategies have failed to significantly improve clinical outcomes due to the lack of individualized precision approaches.
To address this gap, this study proposes to adopt a multicenter, randomized, controlled design, enrolling patients with HFpEF at Stage 4 of CKM syndrome and randomly assigning them to either a personalized high-intensity interval training (HIIT) intervention group or a standard care control group. The **primary endpoint** of this study is the change in peak oxygen consumption (peak VO₂) from baseline after 24 weeks of intervention. In addition, a series of **secondary endpoints** have been established for comprehensive evaluation, including inflammatory biomarkers, cardiac structure and function, quality of life, and composite clinical events. These endpoints aim to comprehensively assess the intervention effects from the perspectives of cardiopulmonary function, metabolism and inflammation, quality of life, and clinical outcomes, as well as to explore the underlying mechanisms.
This study is expected to validate the beneficial effects of personalized exercise on peak VO₂ and various secondary endpoints in patients with Stage 4 CKM syndrome. It will not only provide high-level evidence-based support for exercise therapy in HFpEF but also deepen the understanding of the role of exercise intervention in the full-course management of CKM syndrome, offering key scientific support for the development of precision prevention and treatment strategies across all stages.
Inclusion: Men and women aged 35-70 years; Physical inactivity / sedentary lifestyle defined as:; Sedentary behavior: average daily sitting time > 6 hours over the past 6 months; AND/OR Insufficient physical activity: average weekly moderate-intensity physical activity < 150 minutes or vigorous-intensity physical activity < 75 minutes as assessed by the International Physical Activity Questionnaire (IPAQ); Patients with HFpEF at Stage 4 of CKM syndrome who have been clinically stable within the past month (New York Heart Association [NYHA] functional class II-III); Willingness to improve health status through appropriate exercise.
Exclusion: Diagnosis of psychiatric disorders; Presence of movement disorders or lower extremity exercise-related injuries within the past 6 months; Other conditions deemed unsuitable for participation in this study by the investigators; Presence of contraindications to cardiopulmonary exercise testing (CPET); Positive findings on the exercise electrocardiogram (ECG) during CPET; Women who are pregnant, breastfeeding, or planning to become pregnant in the near future; Refusal to sign the informed consent form.