Senescence in Myocardial Infarction
Key facts
- Who runs it
- South Tees Hospitals NHS Foundation Trust
- Where
- United Kingdom1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Terminated
- People taking part
- 22 people enrolled
- Started
- 8 May 2024
- Ended
- 26 Feb 2026
- Type of study
- Observational, 2 groups
- Record updated
- 9 July 2026
- Why it stopped
- Staffing challenges and subsequent withdrawal of funding.
Who can take part
- Age
- 40 years to 80 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Male and female patients aged 40 to 80 years old undergoing coronary artery bypass graft surgery for myocardial infarction or for stable angina
Who cannot take part
- patients who have had previous cardiac surgery
- patients with ST-elevation myocardial infarction requiring coronary angioplasty
- patients who have evidence of ongoing heart failure,
- need for pre-operative mechanical cardiac support
- >Stage 4 chronic kidney disease
- a left ventricular ejection fraction of less than 30%
- Individuals with pre-existing acute kidney injury
- Sepsis
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The investigators of this study have found that after a heart attack, some heart cells rapidly age (become senescent) and release proteins that make the heart disease worse.
Read full original descriptionShow less
The investigators of this study would like to check for these aged-cell proteins in participants who have coronary artery bypass graft (CABG) surgery after a recent heart attack or to treat more stable heart disease.
The investigators will do this by taking blood samples and a sample of normally discarded heart tissue from each group of participants. This might help tell us who is at the highest risk of developing heart disease and how people recover from a heart attack.
The 2 groups in the trial
- Myocardial Infarction Group
Patients who are undergoing CABG surgery for Non-ST segment elevation myocardial infarction (NSTEMI)
- Stable Angina Group
Patients who are undergoing CABG surgery for stable angina
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Coronary Artery Bypass Surgery After Myocardial Infarction: Identifying Clinical Outcomes by Analysing the Senescence Associated Secretory Phenotype
- Record updated
- 9 July 2026