Hyaluronidase Injections Into the Fingers for Tight Skin in Systemic Sclerosis
Tests hyaluronidase injected into the fingers of adults with systemic sclerosis.
Key facts
- Who runs it
- Medical University of South Carolina
- Where
- Charleston, United StatesSee the site
- Trial code
- Registry title
- Hyaluronidase for Sclerodactyly in Systemic Sclerosis Trial
- Status
- Not yet recruiting
- Phase
- Early phase 1
- People taking part
- 10 people, planned
- Started
- 1 Nov 2026
- Expected to end
- Nov 2027
- Type of study
- Interventional
- Treatments tested
- Hyaluronidase (Hylenex)
- Record updated
- 16 October 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with systemic sclerosis who have sclerodactyly (tight, thickened skin on the fingers). It tests hyaluronidase injections into the skin of the fingers.
- Age
- 18 years or older and younger than 60 years.
- Sex
- Women and men can both join.
- Disease stage
- Diagnosis of systemic sclerosis with sclerodactyly.
- Earlier treatment
- No recent changes in systemic immunomodulatory therapy.
Main reasons for not taking part
- Known allergy (hypersensitivity) to hyaluronidase
- Pregnancy or breastfeeding
- Unstable systemic disease
- Recent changes in systemic immunomodulatory therapy
- Conditions that make injections into the fingers unsafe
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Age ≥18 and <60 years
- Diagnosis of systemic sclerosis
- Presence of sclerodactyly
- Ability to provide informed consent
Who cannot take part
- Recent changes in systemic immunomodulatory therapy
- Known hypersensitivity to hyaluronidase
- Unstable systemic disease
- Conditions interfering with safe digital injections
- Pregnancy or breastfeeding
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Where in United States
- Medical University of South CarolinaCharleston, United StatesContact: Kimberly Hashemi, MDNo longer taking part
About the trial
What the trial wants to find out
Translational studies have demonstrated reduced hyaluronidase activity in the skin of patients with systemic sclerosis. It is thought this may contribute to the progressive fibrosis seen in this disease. Several studies have demonstrated that exogenous hyaluronidase is very effective at improving systemic sclerosis associated microstomia. Therefore, this study aims to explore hyaluronidase for systemic sclerosis associated sclerodactyly.
The group in the trial
- Intradermal HyaluronidaseTreatment being tested
Treatment: Hyaluronidase (Hylenex)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Digital Intradermal Hyaluronidase for Sclerodactyly in Systemic Sclerosis
- Plain-language title
- Hyaluronidase Injections Into the Fingers for Tight Skin in Systemic SclerosisGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07697274, who can take part
- Record updated
- 16 October 2026