Eating Durian Daily in Adults With Type 2 Diabetes
Tests daily durian in adults with type 2 diabetes, checking gut bacteria and blood sugar.
Plain-language title generated from the registry record
Registry title: Durian Consumption in Adults With Type 2 Diabetes Mellitus
Key facts
- Where
- Singapore, SingaporeSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 21 and 70 years old?
Source: NCT07697612, who can take part
Where in Singapore
- Singapore General HospitalSingapore, SingaporeNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Singapore General Hospital
- Trial code
- NCT07697612
- Record updated
- 13 July 2026
- Original description
This single-arm clinical trial investigates the effects of daily durian consumption on the gut microbiome, host metabolome, and glucose metrics in adults with type 2 diabetes mellitus (T2DM). Forty adults with T2DM will undergo a pre-durian phase, a durian consumption phase, and a post-durian phase, each lasting 10 to 14 days. Participants will attend five visits at Singapore General Hospital for clinical assessments, continuous glucose monitoring, fasting blood collection, stool sample collection, and dietary and stool record submission. The study aims to determine whether durian consumption alters microbiome and metabolomic profiles and whether it affects glycemic measures in adults with T2DM.Read full original descriptionShow less
Durian Consumption on Human Microbiome and Metabolome in Adults With Type 2 Diabetes Mellitus (DURIOME-T2D)
This single-arm clinical trial investigates the effects of daily durian consumption on the gut microbiome, host metabolome, and glucose metrics in adults with type 2 diabetes mellitus (T2DM). Forty adults with T2DM will undergo a pre-durian phase, a durian consumption phase, and a post-durian phase, each lasting 10 to 14 days. Participants will attend five visits at Singapore General Hospital for clinical assessments, continuous glucose monitoring, fasting blood collection, stool sample collection, and dietary and stool record submission. The study aims to determine whether durian consumption alters microbiome and metabolomic profiles and whether it affects glycemic measures in adults with T2DM.
Inclusion: Age 21 to 70 years; Diagnosis of type 2 diabetes mellitus; Agrees to consume durian for 2 weeks; Body mass index 25 to 40 kg/m².
Exclusion: Previous gastrointestinal surgeries, including cholecystectomy, gastrectomy, bariatric surgery, or colectomy; Systemic steroid use; Weight loss medications, including GLP-1 receptor agonists, orlistat, or phentermine; Known or suspected intolerance or allergy to durian; Inflammatory bowel disease; Current hemorrhoids or piles causing rectal bleeding during stool passage; Uncontrolled thyroid disease; Any factor likely to limit adherence to study protocol, including dementia, substance abuse, poor appointment adherence, or family concerns regarding participation; Known skin reaction to adhesives used in a continuous glucose sensor; Uncontrolled diabetes (HbA1c greater than 8.5%); Severe hypertriglyceridemia (triglycerides greater than 4.5 mmol/L); ALT greater than 3 times upper limit of normal; AST greater than 3 times upper limit of normal; Smoking; Glomerular filtration rate less than 30 mL/min; Liver cirrhosis; Significant alcohol consumption, defined as more than 20 g/day for women and more than 30 g/day for men; Pregnant, breastfeeding, or intending to conceive during the study; Insulin use; Antibiotic, prebiotic, probiotic, vitamin C, or traditional Chinese medicine use in the last 1 month.