Tests noninvasive brain stimulation for Parkinson's disease and related syndromes
Tests a noninvasive brain stimulation device in adults with Parkinson's disease and related conditions.
Plain-language title generated from the registry record
Registry title: Temporal Interference Noninvasive Deep Brain Stimulation for Idiopathic Parkinson's Disease and Parkinsonian Syndromes: Effects and Target Exploration
Key facts
- Where
- Shanghai, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 80 years old?
Source: NCT07698236, who can take part
Where in China
- Shanghai Jiao Tong University School of Medicine Affiliated Ruijin HospitalShanghai, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Ruijin Hospital
- Trial code
- NCT07698236
- Record updated
- 13 July 2026
- Original description
This study aims to explore the therapeutic effects of noninvasive deep brain electrical stimulation using temporal interference principles (Temporal Interference Stimulation, TIS) on both motor and non-motor symptoms in patients with idiopathic Parkinson's disease and Parkinsonian syndromes, and to investigate strategies for optimal stimulation target selection. A prospective, single-center, double-blind, randomized, crossover design will be implemented. Participants will be recruited from outpatient and inpatient departments of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. The primary hypothesis is that TIS will significantly improve motor symptoms in patients with Parkinson's disease and Parkinsonian syndromes. The primary outcome measure will be the change in the MDS-UPDRS Part III score from baseline to post-stimulation.Read full original descriptionShow less
A Study on the Therapeutic Effects and Target Exploration of Temporal Interference-Based Noninvasive Deep Brain Stimulation in Patients With Idiopathic Parkinson's Disease and Parkinsonian Syndromes
This study aims to explore the therapeutic effects of noninvasive deep brain electrical stimulation using temporal interference principles (Temporal Interference Stimulation, TIS) on both motor and non-motor symptoms in patients with idiopathic Parkinson's disease and Parkinsonian syndromes, and to investigate strategies for optimal stimulation target selection. A prospective, single-center, double-blind, randomized, crossover design will be implemented. Participants will be recruited from outpatient and inpatient departments of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. The primary hypothesis is that TIS will significantly improve motor symptoms in patients with Parkinson's disease and Parkinsonian syndromes. The primary outcome measure will be the change in the MDS-UPDRS Part III score from baseline to post-stimulation.
This study is expected to provide direct evidence supporting the clinical application and target selection strategies of noninvasive deep brain stimulation for the treatment of Parkinson's disease and Parkinsonian syndromes.
Inclusion: Aged 40 to 80 years, diagnosed with idiopathic Parkinson's disease or Parkinsonian syndromes according to the Movement Disorder Society (MDS) diagnostic criteria; Receiving stable doses of levodopa or other dopaminergic medications for at least 4 weeks prior to enrollment, with a documented response to levodopa; medication regimen must remain unchanged during the study; Hoehn and Yahr (H\&Y) stage ≤ 3 in the "ON" medication state; Normal cognitive function, defined as a Mini-Mental State Examination (MMSE) score ≥ 24; Able to maintain and cooperate with Parkinson's disease symptom diaries; Signed written informed consent.
Exclusion: Previous treatment with deep brain stimulation (DBS) or other invasive brain stimulation therapies; Presence of other neurological or psychiatric disorders that may interfere with study participation or outcomes; Orthopedic or other medical conditions that could affect gait or balance; History of taking antipsychotic, antidepressant, or other medications that may affect dopamine levels; Contraindications to electrical stimulation, such as implanted cardiac pacemakers or a history of epilepsy; History of electroconvulsive therapy (ECT); Severe comorbidities, including cardiovascular disease, respiratory disease, or hepatic/renal dysfunction; Contraindications to MRI, such as claustrophobia or other factors making MRI unsuitable.