Predicting Multiple Sclerosis After a First Episode of Optic Neuritis Using Genetic Information
Studies whether genetic and clinical information can predict multiple sclerosis after a first optic neuritis.
Key facts
- Who runs it
- King's College London
- Where
- London, United KingdomSee the 3 sites
- Trial code
- Registry title
- Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool
- Status
- Not yet recruiting
- People taking part
- 180 people, planned
- Started
- 1 Sept 2026
- Expected to end
- 1 Dec 2027
- Type of study
- Observational
- Treatments tested
- No Intervention: Observational Cohort
- Record updated
- 15 July 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 16 and over who have had an episode of optic neuritis (inflammation of the nerve of the eye) diagnosed at a taking-part site. It studies whether genetic and clinical information can help predict a later multiple sclerosis (MS) diagnosis.
- Age
- 16 years and older
- Sex
- All sexes can join.
- Disease stage
- A previous episode of optic neuritis diagnosed at one of the taking-part sites.
Main reasons for not taking part
- Data about the first optic neuritis episode are not available in the medical record at a taking-part site
- Under 16 years old at the time of recruitment
The registry criteria, word for word
Show all 4 criteriaShow less
Who can take part
- Aged 16 years and above at time of consent
- Previous episode of optic neuritis diagnosed at one of the participating sites
Who cannot take part
- Children <16 years at the time of recruitment
- Patients for whom data relating to the first episode of ON are not available in the medical record at a participating site
Where in United Kingdom
- Guy's and St Thomas' NHS Foundation TrustLondon, United KingdomContact: Tasanee Braithwaite, FRCOphthNot yet recruiting
- King's College Hospital NHS Foundation TrustLondon, United KingdomContact: James McHugh, FRCOphthNot yet recruiting
- Moorfields Eye Hospital NHS Foundation TrustLondon, United KingdomContact: Neringa Jurkute, MD, PhD, FEBOphthNot yet recruiting
About the trial
What the trial wants to find out
The goal of this observational study is to determine whether genetic information, together with clinical information, can be used to improve prediction of future multiple sclerosis (MS) diagnosis after a first-time episode of optic neuritis. The study will also investigate visual outcomes, quality of life, healthcare use, and the acceptability of using genetic information to predict future health outcomes in people with optic neuritis.
Read full original descriptionShow less
The main outcomes that we aim to assess are:
1. Incident diagnosis of MS following a first episode of optic neuritis, including time to MS diagnosis. 2. Visual outcomes following optic neuritis, including visual acuity, visual field, and colour vision. 3. Clinical care received following optic neuritis, including specialist review, investigations/tests 4. Health-related and vision-related quality of life. 5. Health economic impacts and healthcare utilisation after experiencing optic neuritis 6. Knowledge, attitudes, and practices/behaviours about using genetic information to predict future MS disease risk.
If consented, participants will:
1. Allow researchers to review information from their medical records relating to their optic neuritis diagnosis, investigations, treatments, and outcomes. 2. Be invited to provide a saliva sample for genetic analysis. 3. Complete questionnaires about their lifestyle/risk factors, quality of life, and views on genetic risk prediction. 4. Allow researchers to track long-term health outcomes using information from their NHS records
The group in the trial
- Participants Who Have Experienced Optic Neuritis
Participants with a history of a first episode of optic neuritis recruited from the 3 participating NHS hospitals. Participants will undergo retrospective review of clinical records, complete questionnaires, and may provide a saliva sample for genetic analysis. Participants will be invited to consent to longer term prospective outcome assessment.
Treatment: No Intervention: Observational Cohort
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool (MS Predictor)
- Plain-language title
- Predicting Multiple Sclerosis After a First Episode of Optic Neuritis Using Genetic InformationGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 15 July 2026