Faster Fluid Removal During Dialysis for Kidney Failure Patients Hospitalized With Fluid Overload
Compares faster and standard fluid removal during dialysis in hospitalized adults with kidney failure.
Plain-language title generated from the registry record
Registry title: The FILTRATE Trial: High-Rate Ultrafiltration for Intravascular Congestion
Key facts
- Where
- Monterrey, MexicoSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults on long-term hemodialysis who are in hospital with too much fluid in the body. It compares a standard fluid removal rate with a higher one.
- Age
- Over 18 years old.
- Sex
- All sexes can join.
- Disease stage
- End-stage kidney disease on hemodialysis for at least 3 months, in hospital with acute fluid overload and clear ultrasound signs of severe congestion. Blood pressure must be stable, at least 120/80 mmHg.
- Earlier treatment
- Hemodialysis for at least 3 months. The trial starts at the first in-hospital session that needs fluid removal.
- Biomarker or test result
- Ultrasound shows severe congestion, such as diffuse B-lines in the lungs or altered VExUS vascular flow patterns.
Main reasons for not taking part
- Low blood pressure (<100/60 mmHg) or active shock
- Heart attack (acute coronary syndrome), severe heart valve disease, or severe fluid around the heart
- Known chronic lung disease
- Pregnancy
This trial only enrols participants on dialysis. The registry sentence this rests on: Adults over 18 years old with End-Stage Renal Disease on hemodialysis for at least 3 months.
Read by machine on 12 November 2026.
Where in Mexico
- Hospital Universitario Dr. Jose E. GonzalezMonterrey, MexicoContact: Edgar Adrián Montemayor, Nephrology FellowTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Universidad Autonoma de Nuevo Leon
- Trial code
- NCT07705269
- Record updated
- 15 July 2026
- Original description
The purpose of this study is to evaluate whether a personalized, high-rate fluid removal strategy guided by ultrasound is as safe and effective as the standard fluid removal rate for patients with advanced kidney disease who are hospitalized due to severe fluid overload (congestion).Read full original descriptionShow less
FluId removaL With a High Rate ulTRAfiltration Protocol in paTiEnts With Intravascular Congestion: the FILTRATE Trial
The purpose of this study is to evaluate whether a personalized, high-rate fluid removal strategy guided by ultrasound is as safe and effective as the standard fluid removal rate for patients with advanced kidney disease who are hospitalized due to severe fluid overload (congestion).
When patients with End-Stage Renal Disease (ESRD) on chronic hemodialysis are admitted to the hospital with excess fluid, doctors often need to remove this fluid quickly to relieve symptoms like severe shortness of breath. However, traditional guidelines recommend conservative fluid removal rates-called ultrafiltration (UF) rates-between 10 and 13 mL/kg/h to prevent sudden drops in blood pressure (intradialytic hypotension). Despite these guidelines, doctors in real-world hospital settings frequently use higher rates to provide urgent relief, though this practice lacks strong scientific backing.
This study utilizes advanced bedside ultrasound protocols (such as lung ultrasound and VExUS) to objectively measure the amount of fluid congestion inside the patient's blood vessels. The researchers hypothesize that patients with high ultrasound markers of congestion can safely tolerate higher fluid removal rates because their blood vessels are overfilled, meaning fluid can be pulled out faster without causing blood pressure drops.
Participants will be randomly assigned to one of two groups during their first in-hospital hemodyalisis session:
* Standard Group: Receives a standard fluid removal rate of 10 mL/kg/h. * High-Rate Group: Receives a higher fluid removal rate of over 13 mL/kg/h (with a safety ceiling up to 15 mL/kg/h).
The study will compare the two groups over the first 24 hours to monitor blood pressure stability (safety) and check for improvements in ultrasound congestion scores, shortness of breath, and the need for supplemental oxygen (effectiveness).
Inclusion: Adults over 18 years old with End-Stage Renal Disease on hemodialysis for at least 3 months; Admitted to the hospital requiring mechanical fluid removal for acute fluid overload (first in-hospital session); Clear ultrasound evidence of severe intravascular congestion (such as diffuse B-lines in the lungs or altered VExUS vascular flow patterns); Hemodynamically stable with a baseline blood pressure of at least 120/80 mmHg.
Exclusion: Acute coronary syndrome (heart attack), severe heart valve disease, or severe fluid around the heart; Known chronic lung disease; Baseline low blood pressure (<100/60 mmHg) or active shock (cardiogenic, septic, or distributive); Pregnancy.