Fractional CO2 laser plus corticosteroid cream for psoriasis of the palms and soles
Compares laser plus corticosteroid cream with cream alone in adults with palm and sole psoriasis.
Key facts
- Who runs it
- Cairo University
- Where
- Cairo, EgyptSee the site
- Trial code
- Registry title
- Combined Fractional CO₂ Laser and Topical Corticosteroid Versus Topical Corticosteroid Only in the Treatment of Palmoplantar Psoriasis
- Status
- Not yet recruiting
- Phase
- Phase 4
- People taking part
- 32 people, planned
- Started
- 15 Aug 2026
- Expected to end
- 15 Feb 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Fractional CO2 laser assisted drug delivery
- Topical Corticosteroid (TCS)
- Record updated
- 20 July 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with stable palmoplantar psoriasis (psoriasis of the palms and soles). It tests whether adding fractional CO2 laser to a steroid cream works better than the cream alone.
- Age
- From 18 to 60 years.
- Sex
- All sexes can join.
- Disease stage
- Stable psoriasis. Palmoplantar psoriasis confirmed by dermoscopy (and by tissue testing if needed), with or without psoriasis elsewhere on the body.
- Earlier treatment
- Cannot have had treatment for psoriasis that works through the whole body within 3 months, biologic therapy within 12 weeks, or cream or ointment on the palms or soles within 2 weeks.
Main reasons for not taking part
- Other skin diseases of the palms and soles (eczema, tinea, keratoderma)
- Generalized pustular psoriasis
- Erythrodermic psoriasis
- Pregnancy or breastfeeding
- History of photosensitivity disorders
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- Adults aged ≥18 years
- Stable psoriasis
- Confirmed cases of palmoplantar psoriasis (with or without psoriasis elsewhere) dermoscopically(Hand _held dermoscopy) and histopathologically if required
- Willingness to comply with treatment and follow-up
- Written informed consent obtained
Who cannot take part
- Use of:; Systemic antipsoriatic therapy within 3 months; Biologic therapy within 12 weeks; Topical treatment on palms/soles within 2 weeks
- History of photosensitivity disorders
- Other palmoplantar dermatoses (eczema, tinea, keratoderma)
- Generlized Pustular psoriasis
- Erythrodermic psoriasis
- Pregnancy or lactation
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Where in Egypt
- Cairo UniversityCairo, EgyptContact: Amira Elbendary, MDNo longer taking part
About the trial
What the trial wants to find out
To assess whether adding fractional laser to topical corticosteroid improves treatment outcomes in palmoplanter psoriasis compared to topical corticosteroid alone.
The 2 groups in the trial
- fractional carbon dioxide (CO₂) laser-assisted delivery of topical corticosteroidsTreatment being tested
fractional carbon dioxide (CO₂) laser-assisted delivery of topical corticosteroids will be done on palmoplantar psoriasis every 4 weeks
Treatment: Fractional CO2 laser assisted drug delivery
- Topical corticosteroids aloneExisting treatment, for comparison
Application of topical corticosteroid alone in patients with palmoplantar psoriasis daily.
Treatment: Topical Corticosteroid (TCS)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Comparative Study of the Efficacy and Safety of Combined Fractional CO₂ Laser and Topical Corticosteroid Versus Topical Corticosteroid Only in the Treatment of Palmoplantar Psoriasis: A Pilot Randomized Controlled Clinical Trial
- Plain-language title
- Fractional CO2 laser plus corticosteroid cream for psoriasis of the palms and solesGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07713212, who can take part
- Record updated
- 20 July 2026