Eye scans to help diagnose and monitor multiple sclerosis, Alzheimer's, Parkinson's and headache disorders
Uses retinal scans in adults with brain diseases and healthy volunteers.
Plain-language title generated from the registry record
Registry title: Optical Coherence Tomography in Neurological Practice: Utility and Applicability Across Neurological Diseases (OCt.IN.N)
Key facts
- Where
- Milan, ItalySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with multiple sclerosis, Alzheimer's disease, Parkinson's disease or migraine/headache, and for healthy adults as controls. Everyone has eye scans (OCT) over 24 months.
- Age
- Older than 18 years.
- Sex
- All sexes can join.
- Disease stage
- A diagnosed disease of the central nervous system: multiple sclerosis, Alzheimer's disease, Parkinson's disease or migraine/headache. Healthy controls must have no neurological disease.
Main reasons for not taking part
- Known or confirmed eye disease found during the examination
- Cannot understand the instructions given by the investigators
- Refuses to take part or withdraws consent
- Any condition that the investigators think makes the person unsuitable for the study
- Epilepsy or past seizures, for patients having certain imaging modes with clearly visible light
Read by machine on 9 November 2026.
Where in Italy
- IRCCS Ospedale San Raffaele - Neurology and Neurophysiology UnitMilan, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- IRCCS San Raffaele
- Trial code
- NCT07720765
- Record updated
- 22 July 2026
- Original description
OCt.IN.N is a national, monocentric, prospective, observational cohort study evaluating the utility and applicability of Optical Coherence Tomography (OCT) in the diagnostic workup and longitudinal monitoring of neurological diseases.Read full original descriptionShow less
A National, Monocentric, Prospective Cohort Study to Evaluate the Utility and Applicability of Optical Coherence Tomography in Neurological Clinical Practice
OCt.IN.N is a national, monocentric, prospective, observational cohort study evaluating the utility and applicability of Optical Coherence Tomography (OCT) in the diagnostic workup and longitudinal monitoring of neurological diseases.
840 patients with Central Nervous System neurological diseases (Multiple Sclerosis, Alzheimer's disease, Parkinson's disease, migraine/headache) and 210 age-matched healthy controls will undergo OCT examination at baseline and at 6, 12, 18, and 24 months of follow-up at IRCCS San Raffaele Hospital, Milan, Italy.
OCT is a non-invasive, rapid, and reproducible technique that automatically measures the thickness of individual retinal layers. Retinal layer thicknesses and their longitudinal changes will be correlated with established clinical scales, neuroimaging, and biological markers used in routine neurological practice.
Inclusion: Diagnosis of a Central Nervous System neurological disease (inflammatory diseases such as Multiple Sclerosis; neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease; migraine/headache) according to currently accepted diagnostic criteria for each condition; Age greater than 18 years; Signed informed consent to study participation; Willingness and ability to undergo all study visits and procedures; Absence of neurological disease; Age greater than 18 years; Signed informed consent to study participation; Willingness and ability to undergo all study visits and procedures.
Exclusion: For specific imaging modes using clearly visible light sources (MultiColor, FA, BAF): diagnosis of epilepsy or history of previous epileptic seizures; Presence of any condition that, in the investigators' opinion, renders the subject unsuitable for the study; Presence of any condition that, in the investigators' opinion, renders the subject unsuitable for the study; Refusal to participate or withdrawal of informed consent; Known or confirmed ocular pathology identified during examination (ophthalmological evaluation may be requested at the investigators' discretion); Inability to understand instructions given by investigators; Refusal to participate or withdrawal of informed consent; Known or confirmed ocular pathology identified during examination; Inability to understand instructions given by investigators.