Physical Activity and Nerve Coating Changes in Older Adults With Multiple Sclerosis
Looks at whether physical activity relates to myelin changes in older adults with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Combating Age-related Failure of Myelination in Multiple Sclerosis: An Exploratory Study
Key facts
- Where
- Seattle, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 70 years old?
Source: NCT07723599, who can take part
Where in United States
- Multiple Sclerosis Center at UW Medical Center - NorthwestSeattle, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Washington
- Trial code
- NCT07723599
- Record updated
- 23 July 2026
- Original description
This observational, longitudinal study will examine whether physical activity and other potentially modifiable lifestyle factors are associated with changes in myelin, the protective coating around nerve fibers, in older adults with multiple sclerosis (MS). Participants will undergo magnetic resonance imaging (MRI) scans to measure myelin throughout the central nervous system and will wear wrist-worn activity trackers to assess physical activity over time.Read full original descriptionShow less
Combating Age-related Failure of Myelination in Multiple Sclerosis: an Exploratory Study
This observational, longitudinal study will examine whether physical activity and other potentially modifiable lifestyle factors are associated with changes in myelin, the protective coating around nerve fibers, in older adults with multiple sclerosis (MS). Participants will undergo magnetic resonance imaging (MRI) scans to measure myelin throughout the central nervous system and will wear wrist-worn activity trackers to assess physical activity over time.
Inclusion: Diagnosis of multiple sclerosis; Independent with ambulation (able to walk 500m without aid); Disease duration >10 years; Age 50 to 70 years (inclusive); Be able to read, speak, and understand English.
Exclusion: Diagnosis of other neurologic disease that would interfere with interpretation such as stroke, myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neuromyelitis optica (NMO), and sarcoidosis; Inability to complete study procedures (including obtaining MRI at BMIC and using Fitbit connected to smartphone); Currently participating in another clinical trial on remyelination; Pregnancy. (Pregnancy status will be asked at screening and before each MRI. Pregnancy testing will not be offered as part of this study.).