Two Ways of Removing Bladder Tumours, Each Followed by BCG Treatment
Compares two tumour removal surgeries, both followed by BCG, in non-muscle-invasive bladder cancer.
Plain-language title generated from the registry record
Registry title: Role of ERBT Plus Intravesical BCG in Intermediate-Risk or High-Risk NMBC
Key facts
- Where
- Hong Kong and Sheung Shui, Hong KongSee the 2 sites
Where in Hong Kong
- Prince of Wales HospitalHong Kong, Hong KongTaking people
- North District HospitalSheung Shui, Hong KongNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Chinese University of Hong Kong
- Trial code
- NCT07724886
- Record updated
- 27 October 2026
- Original description
This is a prospective, multi-centre randomised trial comparing between cTURBT plus 1-year BCG therapy, and ERBT plus 1-year BCG therapy, in patients with intermediate-risk or high-risk NMIBC.Read full original descriptionShow less
A Randomised Trial Investigating the Role of Transurethral En Bloc Resection of Bladder Tumour Plus Intravesical Bacillus Calmette-Guerin Therapy, in Patients With Intermediate-Risk or High-Risk Non-Muscle-Invasive Bladder Cancer
This is a prospective, multi-centre randomised trial comparing between cTURBT plus 1-year BCG therapy, and ERBT plus 1-year BCG therapy, in patients with intermediate-risk or high-risk NMIBC.
Inclusion: Age 18 years or above; Fulfil any one of the following three criteria:; Recurrent bladder tumour; Multiple bladder tumours; Any bladder tumour size of >1cm.
Exclusion: EAU low-risk NIMBC as intravesical BCG therapy should not be offered (5); Any prior use of intravesical BCG therapy; Presence or prior history of upper urinary tract malignancy; Presence of clinically significant cardiovascular disease (History of acute myocardial infarction, presence of uncontrolled angina within 3 months before screening, New York Heart Association Class III or IV congestive heart failure, presence of ventricular arrhythmias, or presence of second-degree or third-degree heart block) (16); Presence of GOLD Stage III or IV chronic obstructive pulmonary disease; History of bleeding disorder or use of anti-coagulants; Presence of other active malignancy; EAU very high-risk NMIBC as upfront radical cystectomy should be offered (5); ECOG performance status ≥ 2 (Ambulatory and capable of all self-care but unable to carry our any work activities) (18); Pregnancy.