Testing a Blood Method to Detect Macrotroponin in Heart Attack Patients and Marathon Runners
Tests a blood method that finds macrotroponin in acute coronary syndrome patients and marathon runners.
Plain-language title generated from the registry record
Registry title: HEARTBEAT-TROP. Polyethylene Glycol Precipitation to Unmask Macrotroponin
Key facts
- Where
- Munich, GermanySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with acute coronary syndrome (a heart attack) and healthy marathon runners. It tests a blood test that tells a harmless troponin complex from a real troponin rise.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Acute coronary syndrome: heart attack with or without ST-segment elevation, with at least one high sensitive troponin I or T value above the 99th percentile of reference. Marathon runners: no signs of heart disease.
- Earlier treatment
- Marathon runners must have had heart screening and medical clearance before the race. No other prior treatment is named.
- Biomarker or test result
- Acute coronary syndrome group: troponin I or T above the 99th percentile of reference.
Main reasons for not taking part
- Known macrotroponin (acute coronary syndrome group)
- Terminal renal disease, with a glomerular filtration rate below 10ml per minute (acute coronary syndrome group)
- Coronary artery disease or structural heart disease (marathon runners)
- Diagnosis of cancer
- Pregnancy
Read by machine on 12 November 2026.
Where in Germany
- Technical University MunichMunich, GermanyContact: Simon Wernhart, MD, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Technical University of Munich
- Trial code
- NCT07726420
- Record updated
- 24 July 2026
- Original description
Troponin elevation can, among others, be due to myocardial infarction, acute inflammation or structural heart disease. Formation of macrocomplexes against troponin is an underestimated cause for persistent troponin elevation. Polyethlylene glycol precipitation (PEG) can differentiate macrotroponin from real troponin elevation, but cut-off values for PEG have not been established. PEG is analyzed in patients with acute coronary syndrome undergoing invasive coronary angiography and compared to healthy marathon runners who have undergone cardiological pre-participation screening and have rested for 24 hours.Read full original descriptionShow less
HEARTBEAT-TROP. Testing of Polyethylene Glycol Precipitation to Unmask Macrotroponin in Acute Coronary Syndrome and Marathon Runners.
Troponin elevation can, among others, be due to myocardial infarction, acute inflammation or structural heart disease. Formation of macrocomplexes against troponin is an underestimated cause for persistent troponin elevation. Polyethlylene glycol precipitation (PEG) can differentiate macrotroponin from real troponin elevation, but cut-off values for PEG have not been established. PEG is analyzed in patients with acute coronary syndrome undergoing invasive coronary angiography and compared to healthy marathon runners who have undergone cardiological pre-participation screening and have rested for 24 hours.
Inclusion: Age above 18 years; Group with acute coronary syndrome (ACS): Diagnosis of ACS (ST-segment elevation or non-ST-segment elevation myocardial infarction according to the European Society of Cardiology Guidelines 2023 with at least one measurement of high sensitive troponin I or T above the 99th percentile of reference); Marathon runners: Participation in a marathon following cardiological pre-participation screening and medical clearance for competition. No clinical signs of cardiovascular or structural heart disease.
Exclusion: Patients with acute coronary syndrome: Known macrotroponin, terminal renal disease (glomerular filtration rate below 10ml per minute), diagnosis of cancer, pregnancy; Marathon runners: Coronary artery disease, structural heart disease, diagnosis of cancer, pregnancy.