Comparing two catheter ablation approaches for persistent atrial fibrillation
Compares two catheter ablation strategies in people with persistent atrial fibrillation.
Plain-language title generated from the registry record
Registry title: Empirical Anatomy-Based Ablation vs Emphasize Map-Guided Substrate Ablation in Persistent Atrial Fibrillation : (COMPASS-AF)
Key facts
- Where
- Seoul, South KoreaSee the site
Where in South Korea
- Samsung Medical CenterSeoul, South KoreaNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Samsung Medical Center
- Trial code
- NCT07726901
- Record updated
- 24 July 2026
- Original description
This study is aimed to compare the clinical efficacy of two different catheter ablation strategies in patients with persistent atrial fibrillation.Read full original descriptionShow less
Empirical Anatomy-Based Ablation vs Emphasize Map-Guided Substrate Ablation in Persistent Atrial Fibrillation : (COMPASS-AF)
This study is aimed to compare the clinical efficacy of two different catheter ablation strategies in patients with persistent atrial fibrillation.
Participants will be randomized 1:1 into either the Anatomy-based group or the Emphasize map-guided group
* Anatomy-based group : Pulmonary vein isolation (PVI) using pulsed-field ablation (PFA) with a single-shot multielectrode catheter. * Emphasize map-guided group : PVI using radiofrequency (RF) ablation followed by additional EnSite X-guided pathologic substrate modification.
Participants will be followed for 1 year to compare the incidence of any atrial tachyarrhythmia and other clinical parameters between the two groups.
Inclusion: Adults aged 19 years or older who have voluntarily provided written informed consent to participate in the study; Patients diagnosed with persistent atrial fibrillation (AF) who are scheduled to undergo catheter ablation for AF.
Exclusion: History of prior catheter ablation or MAZE surgery for atrial fibrillation; History of prior open-heart surgery; Patients with end-stage renal disease (ESRD); Heart failure corresponding to New York Heart Association (NYHA) functional class IV; Acute coronary syndrome (ACS) experienced within the past 3 months; Patients with terminal illness and a life expectancy of less than one year; Any other condition that the investigator deems inappropriate for participation in the study; Left atrial (LA) diameter exceeding 60 mm; Women who are pregnant, lactating, or of childbearing potential.