Comparing 1-hour and 3-hour repeat blood tests to diagnose heart attack
Compares repeating a heart blood test after 1 or 3 hours in suspected heart attack.
Plain-language title generated from the registry record
Registry title: Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation
Key facts
- Where
- Aalborg, Bispebjerg, Esbjerg, Gødstrup, Herlev, Hillerød, Hvidovre, Nykøbing Falster, Odense, Svendborg, and Viborg, DenmarkSee the 11 sites
Where in Denmark
- Aalborg University HospitalAalborg, DenmarkNo longer taking part
- Bispebjerg & Frederiksberg HospitalBispebjerg, DenmarkNo longer taking part
- Esbjerg Og Grindsted SygehusEsbjerg, DenmarkNo longer taking part
- Gødstrup Regional HospitalGødstrup, DenmarkNo longer taking part
- Herlev & Gentofte HospitalHerlev, DenmarkNo longer taking part
- Nordsjællands HospitalHillerød, DenmarkNo longer taking part
- Amager-Hvidovre HospitalHvidovre, DenmarkNo longer taking part
- Nykøbing Falster County HospitalNykøbing Falster, DenmarkNo longer taking part
- Odense University HospitalOdense, DenmarkNo longer taking part
- Svendborg HospitalSvendborg, DenmarkNo longer taking part
- Central Jutland Regional Hospital (Viborg Hospital & Silkeborg Hospital)Viborg, DenmarkNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Herlev and Gentofte Hospital
- Trial code
- NCT07727135
- Record updated
- 6 August 2026
- Original description
People with chest pain are often tested for a heart attack using a blood test called high-sensitivity cardiac troponin (hs-cTn). Traditionally, this blood test is repeated 3 hours after the first sample. Newer guidelines recommend repeating the test after 1 hour instead, which may allow patients to receive a diagnosis and leave the hospital sooner.Read full original descriptionShow less
Danish Randomized Trial of Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation
People with chest pain are often tested for a heart attack using a blood test called high-sensitivity cardiac troponin (hs-cTn). Traditionally, this blood test is repeated 3 hours after the first sample. Newer guidelines recommend repeating the test after 1 hour instead, which may allow patients to receive a diagnosis and leave the hospital sooner.
The purpose of the DanRUSH trial is to compare these two strategies: repeating the blood test after 1 hour versus after 3 hours in adults with suspected acute coronary syndrome. The study will evaluate whether the 1-hour strategy is as safe as the 3-hour strategy while reducing the length of hospital stay.
DanRUSH is a nationwide, pragmatic, cluster-randomized trial conducted in emergency- and cardiology departments across Denmark. The results will help determine the best timing for blood testing in patients with suspected heart attack and improve future care for these patients.
Inclusion: Adults (≥18 years) presenting with suspected acute coronary syndrome (ACS) with a clinical indication for high-sensitivity cardiac troponin testing.
Exclusion: ST-segment elevation myocardial infarction (STEMI) identified on the presenting electrocardiogram and requiring immediate reperfusion therapy; Age <18 years.