Blood Proteins in Small Vesicles to Spot Diabetes Risk in Obesity
Tests blood proteins in small vesicles to find adults with obesity at risk.
Plain-language title generated from the registry record
Registry title: Blood-based sEV Proteins for Early Detection of 2 Diabetes
Key facts
- Where
- Luzhou, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 59 years old?
Source: NCT07728591, who can take part
Where in China
- The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversityLuzhou, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hong Kong Baptist University
- Trial code
- NCT07728591
- Record updated
- 30 July 2026
- Original description
The prevalence of diabetes in China is a significant concern. In 2019, 116.4 million adults were living with diabetes, a number expected to climb to 147.2 million by 2045. Type 2 diabetes (T2D) constitutes 95% of these cases . In Hong Kong, T2D affects an estimated 700,000 people, with prevalence keeps rising. Epidemiology data clearly show that obesity and T2D are closely associated. A previous study conducted by the investigators found that integrin-β2 protein levels are significantly increased in the circulating small extracellular vesicles (sEVs) of obese/overweight individuals.Read full original descriptionShow less
Identification of Blood-based sEV Proteins for Early Detection of At-risk Obese Individuals for Type 2 Diabetes
The prevalence of diabetes in China is a significant concern. In 2019, 116.4 million adults were living with diabetes, a number expected to climb to 147.2 million by 2045. Type 2 diabetes (T2D) constitutes 95% of these cases . In Hong Kong, T2D affects an estimated 700,000 people, with prevalence keeps rising. Epidemiology data clearly show that obesity and T2D are closely associated. A previous study conducted by the investigators found that integrin-β2 protein levels are significantly increased in the circulating small extracellular vesicles (sEVs) of obese/overweight individuals.
Given the well-known association between integrin/ECM and the development of insulin resistance, The study hypothesis is that integrin-β2 and ECM1 proteins in the circulating sEVs can be used for the early detection of obese individuals at risk for T2D.This proposed study is critical to provide supporting data for the implementation of a subsequent prospective cohort study to validate whether integrin β2/ECM1 proteins in circulating sEVs can be used for the early detection of obese individuals at risk for T2D.
Inclusion: Hong Kong citizens; Male or female; Aged 40-59 years; Able and willing to provide written informed consent; Willing to undergo BMI assessment and fasting blood collection after an overnight fast of at least 8 hours.
Exclusion: Cardiovascular disease; Cancer; History of surgery, as specified in the study protocol; Infectious disease; Genetic disease; Osteoarthritis; Pregnancy or breastfeeding; Suspected pregnancy.