Blood Markers of Blood Vessel Lining Changes in Children With New High Blood Pressure
Compares blood markers of vessel lining activation in children with and without high blood pressure.
Plain-language title generated from the registry record
Registry title: Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension
Key facts
- Where
- Osijek, CroatiaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 6 and 17 years old?
Source: NCT07728643, who can take part
Where in Croatia
- Faculty of Medicine OsijekOsijek, CroatiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Josip Juraj Strossmayer University of Osijek
- Trial code
- NCT07728643
- Record updated
- 27 July 2026
- Original description
Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their role in pediatric hypertension remains poorly understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive children and children with newly diagnosed, untreated primary hypertension. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury in pediatric hypertension and support the development of non-invasive biomarkers for early cardiovascular risk assessment.Read full original descriptionShow less
Endothelial Extracellular Vesicles as Biomarkers of Blood Pressure-Induced Endothelial Activation in Children With Newly Diagnosed Untreated Primary Hypertension
Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their role in pediatric hypertension remains poorly understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive children and children with newly diagnosed, untreated primary hypertension. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury in pediatric hypertension and support the development of non-invasive biomarkers for early cardiovascular risk assessment.
Inclusion: Children and adolescents aged 6-17 years; Written informed consent from a parent or legal guardian and assent from the participant when appropriate; Normotensive status or newly diagnosed, previously untreated primary hypertension according to current pediatric hypertension guidelines; Ability to comply with study procedures.
Exclusion: Previous antihypertensive treatment; Use of medications known to affect endothelial function; Secondary hypertension; Congenital heart disease or other significant cardiovascular disease; Diabetes mellitus; Chronic kidney disease; Autoimmune or chronic inflammatory disease; Acute infection at the time of enrollment; Malignancy; Inability to comply with study procedures.