Blood Markers of Blood Vessel Activation in Pregnancies With High Blood Pressure
Compares blood vesicle markers in pregnant adults with and without high blood pressure disorders.
Plain-language title generated from the registry record
Registry title: Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy
Key facts
- Where
- Osijek, CroatiaSee the site
Where in Croatia
- Faculty of Medicine OsijekOsijek, CroatiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Josip Juraj Strossmayer University of Osijek
- Trial code
- NCT07728656
- Record updated
- 27 July 2026
- Original description
Hypertensive disorders of pregnancy are associated with endothelial dysfunction and increased maternal and fetal morbidity. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their relationship with blood pressure and endothelial function during pregnancy remains incompletely understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive pregnant women and pregnant women with hypertensive disorders of pregnancy. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury during pregnancy and support the development of non-invasive biomarkers for early detection and monitoring of hypertensive disorders of pregnancy.Read full original descriptionShow less
Endothelial Extracellular Vesicles as Biomarkers of Blood Pressure-Induced Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy
Hypertensive disorders of pregnancy are associated with endothelial dysfunction and increased maternal and fetal morbidity. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their relationship with blood pressure and endothelial function during pregnancy remains incompletely understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive pregnant women and pregnant women with hypertensive disorders of pregnancy. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury during pregnancy and support the development of non-invasive biomarkers for early detection and monitoring of hypertensive disorders of pregnancy.
Inclusion: Pregnant women aged ≥18 years; Singleton pregnancy; Ability to provide written informed consent; Normotensive pregnancy or diagnosis of gestational hypertension or preeclampsia according to current clinical guidelines; Ability to comply with study procedures.
Exclusion: Chronic hypertension diagnosed before pregnancy; Pre-existing diabetes mellitus; Chronic kidney disease; Autoimmune disease; Known cardiovascular disease; Active infection or inflammatory disease; Malignancy; Multiple pregnancy; Inability or unwillingness to provide informed consent.