Eccentric cycling exercise during heart rehabilitation after a heart attack
Tests eccentric cycling exercise in people recovering from a heart attack.
Plain-language title generated from the registry record
Registry title: Eccentric Exercise Rehabilitation After Myocardial Infarction
Key facts
- Where
- Wejherowo, PolandSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 75 years old?
Source: NCT07729410, who can take part
Where in Poland
- Florian Ceynowa Specialist Hospital in WejherowoWejherowo, PolandNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Medical University of Gdansk
- Trial code
- NCT07729410
- Record updated
- 27 July 2026
- Original description
This clinical trial will evaluate a two-week eccentric exercise program conducted as part of comprehensive cardiac rehabilitation in patients after a heart attack (myocardial infarction). Eccentric exercise involves muscle contractions while the muscles are lengthening and may allow the muscles to work at a relatively high load with a lower cardiovascular and metabolic demand than traditional exercise.Read full original descriptionShow less
Effects of Two-Week Eccentric Exercise-Based Cardiac Rehabilitation on Myokines, Exerkines, and Physical Function in Patients After Myocardial Infarction
This clinical trial will evaluate a two-week eccentric exercise program conducted as part of comprehensive cardiac rehabilitation in patients after a heart attack (myocardial infarction). Eccentric exercise involves muscle contractions while the muscles are lengthening and may allow the muscles to work at a relatively high load with a lower cardiovascular and metabolic demand than traditional exercise.
The main aim of the study is to determine whether eccentric exercise affects blood levels of proteins released or regulated in response to physical activity, including musclin, interleukin-6, and myostatin. The study will also evaluate whether the program improves physical performance and functional capacity.
Participants will complete eccentric cycling exercise on a semi-recumbent cycle ergometer during a two-week cardiac rehabilitation program. Blood samples and physical-function measurements will be collected before and after the intervention.
Inclusion: Documented history of myocardial infarction confirmed by medical records; Qualification for stage I comprehensive inpatient cardiac rehabilitation; Clinically stable condition allowing participation in exercise-based cardiac rehabilitation; New York Heart Association functional class I or II; Moderate or good exercise tolerance, defined as an exercise capacity of at least 5 metabolic equivalents, assessed during an exercise test; No cardiovascular contraindications to exercise testing or participation in exercise-based cardiac rehabilitation; Ability to understand the study procedures and follow the instructions provided by the study personnel; Provision of written informed consent to participate in the study.
Exclusion: Acute myocardial infarction within the first 4 days before planned initiation of exercise rehabilitation; Any contraindication to exercise-based cardiac rehabilitation or exercise testing; Unstable angina; Symptomatic cardiac arrhythmias; Decompensated heart failure; Deep vein thrombosis; Symptomatic acquired second- or third-degree atrioventricular block without appropriate cardiac pacing; Poorly controlled arterial hypertension; Recent stroke or transient cerebral ischemic event; Any acute or uncontrolled non-cardiovascular condition that may interfere with exercise testing or worsen during exercise, including febrile illness, clinically significant electrolyte abnormalities, uncontrolled hyperthyroidism, or clinically significant anemia; Physical or cognitive impairment preventing safe completion of the study procedures, exercise testing, or training intervention; Significant left main coronary artery stenosis considered a contraindication to exercise by the treating cardiologist; Symptomatic severe aortic stenosis; Acute pulmonary embolism or pulmonary infarction; Recent or mobile intracardiac thrombus; Acute myocarditis, endocarditis, or pericarditis; Aortic dissection; Inability or unwillingness to provide written informed consent.