Testing nicorandil tablets in adults with rheumatoid arthritis
Tests whether nicorandil tablets can reduce disease activity in adults with rheumatoid arthritis.
Plain-language title generated from the registry record
Registry title: The Effect of Nicorandil on Rheumatoid Arthritis Patients
Key facts
- Where
- Cairo, EgyptSee the site
- Phase
- Phase 2/3
Where in Egypt
- Ain Shams University HospitalsCairo, EgyptTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Ain Shams University
- Trial code
- NCT07730723
- Record updated
- 16 September 2026
- Original description
The aim of this clinical trial is to determine whether nicorandil works in minimizing disease severity in patients with rheumatoid arthritis. The study will also assess the safety and tolerability of nicorandil. The main questions it aims to answer are:Read full original descriptionShow less
The Effect of Nicorandil on Disease Activity in Rheumatoid Arthritis Patients
The aim of this clinical trial is to determine whether nicorandil works in minimizing disease severity in patients with rheumatoid arthritis. The study will also assess the safety and tolerability of nicorandil. The main questions it aims to answer are:
* Could nicorandil improve disease severity and symptoms of rheumatoid arthritis? * Does nicorandil lower the number of times participants need to use pain relieve medications? * Does the nicorandil improve participants functionality and ability to carry out daily activity? * Does nicorandil correct disease-associated damage and inflammation? * What side effects do participants have when taking nicorandil? Researchers will compare nicorandil to a placebo (a look-alike substance that contains no drug) to see if nicorandil works to decrease symptoms and severity of rheumatoid arthritis.
Participants will:
* Take nicorandil or a placebo two times daily for 3 months * Visit the clinic once every month for checkups * Keep a diary of their symptoms and the number of times they use a pain reliever
Inclusion: Adult (≥18 years); Confirmed diagnosis with RA according to ACR/EULAR 2010 criteria; Moderate to severe disease activity (DAS-28 ˃ 3.2); Stable on conventional treatment for at least 3 months; Adequate kidney and liver function.
Exclusion: Patients receiving bDMARDs or tsDMARDs; Use of drugs contraindicated with nicorandil (e.g., sildenafil, tadalafil, vardenafil, tricyclic antidepressants, or guanyl cyclase); Other autoimmune diseases; Malignancy or history of malignancy; Hypersensitivity to nicorandil; Left ventricular heart failure or severe hypotension (SBP ˂100 mmHg); History of cardiogenic shock; History or active gastric ulcer; Poor patient compliance; Pregnancy or lactation.