Studying the blood-brain barrier in people with newly diagnosed glioblastoma
Examines blood-brain barrier changes in adults newly diagnosed with glioblastoma having surgery.
Key facts
- Who runs it
- Patrick Morris
- Where
- Beaumont, IrelandSee the site
- Trial code
- Registry title
- Characterization of the Blood-Brain Barrier in High-Grade Glioma Through Immunohistochemical, Transcriptional, Fluorescein and Radiological Analyses
- Status
- Recruiting
- People taking part
- 100 people, planned
- Started
- 1 Mar 2022
- Expected to end
- 31 Dec 2035
- Type of study
- Interventional
- Treatments tested
- Multimodal Blood Brain Barrier Assessment
- Record updated
- 28 July 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with newly diagnosed glioblastoma who are selected for surgery to remove the tumor. It studies how the blood-brain barrier is affected.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Newly diagnosed glioblastoma, selected for surgical tumor resection
Main reasons for not taking part
- Cannot have an MRI scan (contraindication to MRI)
- Confusion, delirium or altered consciousness that prevents giving informed consent
- Any condition that would prevent completing the study or put safety at risk, in the investigator's opinion
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Adult patients aged 18 years or older
- Newly diagnosed glioblastoma
- Selected for surgical tumor resection
- Able and willing to provide written informed consent
- Able to undergo study assessments and follow-up procedures
Who cannot take part
- Any condition that, in the opinion of the investigator, would prevent completion of study procedures or compromise participant safety
- Contraindication to magnetic resonance imaging
- Confusion, delirium, or altered state of consciousness that interferes with the ability to provide informed consent
Where in Ireland
- Beaumont RCSI Cancer CentreBeaumont, IrelandContact: Aisling Hegarty, RGN, BSc, MSc, PhDTaking people
About the trial
What the trial wants to find out
This prospective study aims to characterize blood brain barrier (BBB) disruption in patients with newly diagnosed glioblastoma multiforme undergoing surgical resection. The study integrates advanced MRI, circulating BBB biomarkers, neurocognitive assessment, and molecular analysis of tumor tissue to investigate relationships between BBB integrity, tumor biology, and neurological function. Participants will undergo serial assessments before surgery, after surgery, and following radiotherapy. Tumor tissue collected during standard-of-care resection will undergo immunohistochemical and transcriptional
The group in the trial
- Blood Brain Barrier Characterisation CohortTreatment being tested
Participants with newly diagnosed glioblastoma will undergo a standardized Phase 2 multimodal assessment program designed to characterize blood-brain barrier integrity. Study interventions include serial advanced contrast-enhanced MRI, blood biomarker sampling, neurocognitive assessments, and molecular analysis of tumor tissue obtained during standard of care surgical resection. Assessments will be performed longitudinally at predefined time points before surgery, after surgery, at 72 hours, at 4 weeks, and following completion of radiotherapy to evaluate changes in blood-brain barrier function and their association with clinical, radiological, and molecular outcomes.
Treatment: Multimodal Blood Brain Barrier Assessment
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Characterization of the Blood-Brain Barrier in High-Grade Glioma Through Immunohistochemical, Transcriptional, Fluorescein and Radiological Analyses
- Plain-language title
- Studying the blood-brain barrier in people with newly diagnosed glioblastomaGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 28 July 2026