Surgery on One Lung Versus Both Lungs for Severe Emphysema
Compares operating on one lung or both in adults with severe emphysema.
Plain-language title generated from the registry record
Registry title: Unilateral vs. Bilateral Lung Volume Reduction Surgery
Key facts
- Where
- Copenhagen, DenmarkSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07731958, who can take part
Where in Denmark
- RigshospitaletCopenhagen, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Copenhagen University Hospital, Rigshospitalet
- Trial code
- NCT07731958
- Record updated
- 28 July 2026
- Original description
This study compares two surgical approaches for patients with severe Chronic Obstructive Pulmonary Disease (COPD) and severe emphysema: unilateral (operating on one lung) versus bilateral (operating on both lungs) lung volume reduction surgery (LVRS).Read full original descriptionShow less
Unilateral Versus Bilateral Lung Volume Reduction Surgery for Patients With Severe COPD
This study compares two surgical approaches for patients with severe Chronic Obstructive Pulmonary Disease (COPD) and severe emphysema: unilateral (operating on one lung) versus bilateral (operating on both lungs) lung volume reduction surgery (LVRS).
Inclusion: Suitable target areas in both lungs; Age ≥ 18 years; Speaks and understands Danish or English; Informed consent obtained; Usual inclusion criteria in LVRS:; Moderate to severe COPD with MRC score > 2 < 75 years old 17 < BMI > 30 FEV1 > 20% and < 45% of predicted RV > 200% of predicted as a sign of relevant hyperinflation DLCO > 20% of predicted The patient should be in ideal medical treatment and have completed rehabilitation A high-resolution CT < 3 months old should follow the referral to MDT Absence of nodules suspicious of malignancy on CT scan Absence of significant comorbidity including severe cardiovascular disease LVEF normal Absence of pulmonary hypertension, TI-gradient < 40 mmHg Absence of chronic or frequent lung infections Smoking abstinence six months prior to surgery Assessed as sufficiently physically fit to undergo surgery and rehabilitation.
Exclusion: Massive adhesions during surgery assessed by the surgeon indicating problems postoperatively; Perioperative decision on not doing operation on the other side (medical, surgical or anaesthesiologic problems that favours a fast termination of the surgery, decided by the team in OR); Previous cardiothoracic surgery; Psychiatric disorder (anxiety, depression, schizophrenia); Simultaneous lung cancer surgery; Increased risk of post-operative bleeding assessed perioperatively by the surgeon; Increased bleeding risk (e.g., preoperative INR >2, overdue discontinuation of anticoagulants according to guidelines by the Danish Society for Thrombosis and Haemostasis, known coagulopathy); Dependent on wheelchair; Living in nursery home; Dependent on walker device.