Breath Analysis as a Possible Way to Detect Cancer Early
Studies chemicals in the breath of adults with several types of cancer.
Key facts
- Who runs it
- University of Oklahoma
- Where
- Oklahoma City, United StatesSee the site
- Trial code
- Registry title
- Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry
- Status
- Not yet recruiting
- People taking part
- 2,000 people, planned
- Started
- Oct 2026
- Expected to end
- Oct 2029
- Type of study
- Observational, 2 groups
- Treatments tested
- Proton Transfer Reaction Mass Spectrometry Analysis
- Record updated
- 29 July 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with any type of cancer, newly diagnosed or established, who are not on active cancer treatment. Breath samples will be analysed.
- Age
- 18 years or older
- Sex
- Men and women can join
- Disease stage
- Cancer of any type. Either newly diagnosed and untreated, or an established diagnosis with no active anti-cancer treatment for more than one month.
- Earlier treatment
- New cancer: untreated. Established cancer: no active anti-cancer treatment for more than one month.
Main reasons for not taking part
- Under 18 years old
- Pregnant women
- Active respiratory infection symptoms
- Recent use of antibiotics
- On active cancer treatment, or treated within one month
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Age ≥ 18 at the time of consent. Male and female patients to be tested
- Capable of understanding written and/or spoken English language
- Able to provide informed consent
- Cancer of any type
- Newly diagnosed cancer and untreated or established diagnosis of cancer. For established cancer patients, no active anti-cancer treatment for more than one month (reasons for no treatment are such as relapse, progression of cancer, refractory, or intolerance to treatment etc.)
Who cannot take part
- Cancer patients who are on active treatment for cancer or have received cancer treatment within one month
- Active respiratory infection symptoms
- Under the age of 18
- Anticipated inability to complete breath sampling procedure
- Unable to provide informed consent
- Pregnant women
- Recent use of antibiotics
- Difficulty in performing coached exhalation
- Individuals who are unable to follow the instructions
Where in United States
- OU Health Stephenson Cancer CenterOklahoma City, United StatesContact: Nirmal Choradia, MDNo longer taking part
About the trial
What the trial wants to find out
The purpose of this clinical trial is to evaluate whether volatile organic compound (VOC) signatures detected in the breath of patients with cancer can serve as a potential screening tool for the early detection of cancer.
The 2 groups in the trial
- Diagnosed Malignancies
Participants in this group either have a newly diagnosed, untreated cancer or a pre-existing cancer diagnosis but are not currently receiving anticancer therapy. Participants with a pre-existing diagnosis must not have received any anticancer treatment within the previous month.
Treatment: Proton Transfer Reaction Mass Spectrometry Analysis
- Healthy Control Group
Participants in this control group have no current or prior diagnosis of a malignancy.
Treatment: Proton Transfer Reaction Mass Spectrometry Analysis
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Breath Volatile Organic Compounds (VOC) Analysis Using Proton Transfer Reaction Mass Spectrometry (PTR-MS)
- Plain-language title
- Breath Analysis as a Possible Way to Detect Cancer EarlyGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 29 July 2026