Eccentric vs Low-Load Blood Flow Restriction Training in Knee Osteoarthritis in Knee Osteoarthritis
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Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 70 years old?
Source: NCT07733518, who can take part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Riphah International University
- Trial code
- NCT07733518
- Record updated
- 7 August 2026
- Original description
The aim of this randomized controlled trial is to find the effects of eccentric and low-load blood flow restriction training on neuromuscular adaptations, muscle strength, functional performance, and disability in patients with knee osteoarthritisRead full original descriptionShow less
Comparison of Eccentric and Low-Load Blood Flow Restriction Training on Neuromuscular Adaptations in Knee Osteoarthritis
The aim of this randomized controlled trial is to find the effects of eccentric and low-load blood flow restriction training on neuromuscular adaptations, muscle strength, functional performance, and disability in patients with knee osteoarthritis
Inclusion: Age group 40-70; Both genders male and female; Clinical diagnosis of knee OA (Kellgren-Lawrence grade 1-3) of the most symptomatic knee; Pain stable enough to permit exercise on Numeric Pain Rating Scale 3/10; Participants must demonstrate a gastrocnemius muscle strength of grade ≥3 on the Manual Muscle Testing (MMT) scale (0-5), assessed using the standard standing heel-rise position; Participants must be able to ambulate independently and participate in supervised exercise.
Exclusion: • Presence of a prosthetic knee in the affected limb; Inflammatory arthritis (e.g., rheumatoid arthritis) or active flare-up of OA; Cardiovascular disease contraindicating exercise (e.g., unstable angina, recent MI, uncontrolled hypertension ≥160/100 mmHg); Pulmonary disease that limits safe participation (e.g., severe COPD, recent exacerbation); History of deep vein thrombosis (DVT), peripheral vascular disease, or bleeding/clotting disorders; Current anticoagulant therapy that increases bleeding risk (unless cleared by physician); Any pathology causing significant muscle weakness (e.g., neuromuscular disorders, severe neuropathy).