Sarcopenia Screening in Advanced Coxarthrosis: The SARCO-COX Study
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- How often do I need to come in, and for how long each time?
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Contact the study team: see the registry record → Contacts and Locations
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- Who runs it
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
- Trial code
- NCT07734129
- Record updated
- 15 September 2026
- Original description
The SARCO-COX study evaluates whether screening for sarcopenia (loss of muscle strength and mass) in adults aged 65 years or older with advanced hip osteoarthritis, followed by a structured postoperative exercise program, improves recovery after total hip replacement surgery compared with standard care.Read full original descriptionShow less
Efficacy of a Sarcopenia Screening Program in Subjects With Advanced Coxarthrosis. SARCO-COX Randomized Intervention Study
The SARCO-COX study evaluates whether screening for sarcopenia (loss of muscle strength and mass) in adults aged 65 years or older with advanced hip osteoarthritis, followed by a structured postoperative exercise program, improves recovery after total hip replacement surgery compared with standard care.
Participants will undergo assessments of muscle strength, muscle mass, physical function, pain, and quality of life before surgery and during follow-up. Blood samples and a small muscle biopsy obtained during the planned surgery will be analyzed to study biomarkers related to muscle health.
A total of 150 people are expected to participate in this study. Participants will be divided into three groups:
* Group 1: People with sarcopenia who will take part in an exercise programme following surgery. * Group 2: People with sarcopenia who will receive the usual care and follow-up after their surgery. * Group 3: people without sarcopenia who are undergoing surgery and will receive the usual care and follow-up.
The study aims to determine whether early identification and targeted rehabilitation of sarcopenia can improve functional outcomes and quality of life after hip replacement.
Inclusion: Subjects age >= 65 years of age; Previous diagnosis of advanced hip osteoarthritis; Patients who are on the surgical waiting list for total joint replacement hip; Barthel Index > 80 points; That they will undergo surgery at the Regional University Hospital of Malaga.
Exclusion: Patients who refuse to accept and sign the informed consent form surgical intervention; Subjects diagnosed with inflammatory or hematological disease; Subjects with coagulation disorders; Subjects with lung disease, heart disease or unstable high blood pressure; Subjects diagnosed with neurodegenerative disease that prevents them from performing physical exercise; Subjects with psychiatric pathology that prevents the performance of physical exercise and adherence to treatment; Patients who refuse to accept and sign the informed consent form participation in the study; Subjects diagnosed with immunodeficiency or undergoing immunosuppressive treatment.