Tests ecnoglutide injection in adults with obesity and knee osteoarthritis
Tests ecnoglutide injection against a placebo in adults with obesity and knee arthritis.
Plain-language title generated from the registry record
Registry title: A Study of Econoglutide Injection in Obese Participants With Knee Osteoarthritis (KOA)
Key facts
- Where
- Wuhan, ChinaSee the site
- Phase
- Phase 3
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with obesity and knee osteoarthritis with knee pain. It compares ecnoglutide injection with a placebo.
- Age
- 18 to 75 years
- Sex
- All sexes can join.
- Disease stage
- Obesity with a BMI of 28.0 kg/m^2 or more. Knee osteoarthritis with moderate changes on X-ray (Kellgren-Lawrence grade 2 or 3). Knee pain lasting more than 12 weeks, and on more than 15 days in the past month. Knee pain score of 4 to 9 on a 0-10 scale.
- Earlier treatment
- A history of unsuccessful weight loss attempts by diet and exercise. No joint replacement of the target knee. No arthroscopy of the target knee in the past 12 months. No hyaluronic acid injection into the target knee in the past 3 months. No oral or muscle corticosteroids in the past 30 days. No corticosteroid injection into any joint in the past 90 days.
Main reasons for not taking part
- Diabetes, or a history of diabetic ketoacidosis or hyperosmolar state/coma
- Body weight change of more than 5% in the past 3 months
- Other joint diseases such as rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis
- Knee instability in the past 12 months, such as a ligament rupture
- Pain elsewhere in the leg or back as bad as or worse than the target knee pain
Read by machine on 13 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07734311, who can take part
Where in China
- Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, ChinaContact: Weihua XU, DrTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Hangzhou Sciwind Biosciences Co., Ltd.
- Trial code
- NCT07734311
- Record updated
- 31 August 2026
- Original description
The main purpose of the study is to evaluate the efficacy and safety of ecnoglutide injections versus placebo in obese participants with KOA.Read full original descriptionShow less
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Study to Evaluate the Efficacy and Safety of Ecnoglutide Injection in Obese Participants With Knee Osteoarthritis (KOA)
The main purpose of the study is to evaluate the efficacy and safety of ecnoglutide injections versus placebo in obese participants with KOA.
Inclusion: Body mass index (BMI) ≥ 28.0 kg/m\^2; The target knee must meet the diagnostic criteria of American College of Rheumatology (ACR) for knee osteoarthritis (clinical and radiological), with moderate radiographic changes (Kellgren-Lawrence grade 2 or 3). The target knee is defined as the knee with the most symptomatic knee at screening period; if pain in both knees are equal, the target knee will be the most dominant leg (preferred leg); Prior to screening, target knee pain lasting more than 12 weeks, and according to participant's self-report or medical history at screening, target knee pain lasting more than 15 days in the past month; At screening and prior to randomization, WOMAC pain score (NRS 0-10) of the target knee must be between 4 and 9 (to avoid bias in reporting, participants must not be informed of the pain score used to determine eligibility for the study); Self-reported by the participant who has a history of unsuccessful weight loss attempt by diet and exercise.
Exclusion: The target knee has undergone joint replacement surgery; The target knee has undergone arthroscopy within 12 months prior to screening; The target knee has received intra-articular injections of hyaluronic acid, any other investigational drugs, or biologics within 3 months prior to screening; or has undergone any procedures that result in persistent sensory loss in the target knee (e.g., ablation) within 6 months prior to screening; Has received any intramuscular or oral corticosteroids (investigational or marketed) within 30 days prior to screening, or has received any intra-articular corticosteroid injections (investigational or marketed) in any joint within 90 days prior to screening; History of joint instability in either knee within 12 months prior to screening, such as anterior cruciate ligament rupture or recent trauma; Presence of symptomatic hip osteoarthritis at the time of screening, with the exception of those who have undergone hip replacement surgery; Change of body weight >5% within 3 months prior to screening (selfreported); At the time of screening, the target knee joint has any clinical features and symptoms of other active infections or crystal-induced arthropathies, as well as any other active joint diseases that may interfere with assessment; History of any other potentially causative and/or confounding diseases, including Reiter's syndrome, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, inflammatory bowel disease-associated arthritis, sarcoidosis, amyloidosis, or fibromyalgia; Conditions that may interfere with the assessment of target knee pain during screening include, but are not limited to:; Pain in any part of the lower limb or back equal to or more severe than the pain in the target knee; Pain radiating to the knee from other areas, such as hip pain affecting the knee or radicular pain; Chronic widespread pain (including neuropathic pain); Diagnosis of diabetes (excluding gestational diabetes), or with a history of diabetic ketoacidosis or hyperosmolar state/coma.