Appetite After Weight Loss in Adults with Overweight or Obesity
Tests whether eating more after weight loss restores normal hunger in adults.
Plain-language title generated from the registry record
Registry title: Weight Loss and Hunger
Key facts
- Where
- Ottawa, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 55 years old?
Source: NCT07739095, who can take part
Where in Canada
- University of OttawaOttawa, CanadaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Ottawa
- Trial code
- NCT07739095
- Record updated
- 31 July 2026
- Original description
Weight loss is difficult and weight maintenance even worse. The principles of dieting dictate that to maintain weight loss, one has to eat less calories than they did before the diet. However, there is evidence to show that it may be the diet per se and not the weight loss that makes people more hungry and vulnerable to weight regain. This study will explore whether appetite control can be restored to normal levels through an individually tailored increase in calories after weight loss. If supported, the findings from this study could alter the way we view dieting.Read full original descriptionShow less
Weight Loss and Hunger: Did we Get it Wrong All This Time?
Weight loss is difficult and weight maintenance even worse. The principles of dieting dictate that to maintain weight loss, one has to eat less calories than they did before the diet. However, there is evidence to show that it may be the diet per se and not the weight loss that makes people more hungry and vulnerable to weight regain. This study will explore whether appetite control can be restored to normal levels through an individually tailored increase in calories after weight loss. If supported, the findings from this study could alter the way we view dieting.
Inclusion: 18-55 years of age; non-smoking; obese class I-II (30 kg/m2 ≤ BMI < 40 kg/m2); weight stable (± 2 kg during the 6 months prior to enrollment); Sedentary (<2 times/week of 30 min of continuous exercise); In addition, Females will be included if:; premenopausal (2 menses in the 3 months preceding testing, no increase in cycle irregularity in the 12 months preceding testing).
Exclusion: currently use antidepressants, thyroid medication, or any medication that could affect appetite; currently taking monoamine oxidase inhibitors, pressor agents, warfarin, anticonvulsants, phenylbutazone, or tricyclic antidepressants; have a current diagnosis of an axis 1 psychiatric disorder (i.e. mood, anxiety and eating disorders); have a history of cardiac problems or symptoms suggestive of any cardiac condition; have uncontrolled thyroid disease; have any osteoarticular condition, or other reasons that would prevent them from achieving the proposed walking targets; In addition, Females will be excluded if they:; have a current diagnosis or history of diabetes, confirmed by a measure of HbA1c during the screening visit; have alcohol intake that exceeds recommendations or alcoholism, or current addictions to opiates, cocaine or stimulants; are pregnant or planning to become pregnant over the course of the study; are peri- or post-menopausal or have had surgically induced menopause.