Olive oil phenolic supplement for people with mild cognitive impairment
Tests an olive oil phenolic supplement against placebo in people with mild cognitive impairment.
Plain-language title generated from the registry record
Registry title: Assessing Treatment With High-phenolic EVOO Supplements for Neurovascular Activity
Key facts
- Where
- Augusta, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 70 years old?
Source: NCT07741773, who can take part
Where in United States
- Georgia prevention instituteAugusta, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Augusta University
- Trial code
- NCT07741773
- Record updated
- 3 November 2026
- Original description
The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are:Read full original descriptionShow less
Dietary Supplementation With EVOO Phenolics Prevents MCI Progression to Alzheimer's Disease
The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are:
* Does dietary supplementation with EVOO phenolics improve cognitive function? * What would be the effect of the EVOO dietary supplement on other MCI-related biomarkers, including vascular function and biological pathways?
Researchers will compare the EVOO dietary supplements with a placebo (a look-alike substance that contains no EVOO phenolics)
Participants will:
* Take EVOO dietary supplements or a placebo daily for 6 months * Visit the study site during the 6-month study for screening and testing.
Inclusion: CDR (Clinical Dementia Rating) score of 0.5 OR MoCA (Montreal Cognitive Assessment) score of 18-25.
Exclusion: History or presence of vascular disease that may affect cognitive function; History or presence of stroke within the past 1 year; History of severe, clinically significant CNS trauma; History of intracranial tumor; Allergic to the MRI contrast agent "Multihance"; History or presence of kidney disease (eGFR <60 mL/min/1.73m2); Recent transient ischemic attack (TIA) within the past 180 days; Presence of a pacemaker; Presence of metal in the body; Pregnancy.