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Value of Biomarkers of Brain Injury for Predicting Psycho-cognitive Sequelae Secondary to Sepsis: a Prospective Multicenter Study

Key facts

Who runs it
Assistance Publique - Hôpitaux de Paris
Where
France1 site in 1 countryChoose a country to see its sites
Trial code
Status
Not yet recruiting
People taking part
210 people, planned
Started
Sept 2026
Expected to end
Aug 2028
Type of study
Interventional
Treatments tested
  • Serum
Record updated
4 August 2026

Who can take part

Age
18 years to 80 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 14 criteriaShow less

Who can take part

  • Adults aged 18-80 years
  • Admission to a medical or mixed ICU
  • Sepsis or septic shock according to Sepsis-3 criteria
  • ICU admission for less than 24 hours
  • Need for invasive or non-invasive mechanical ventilation and/or vasopressor support
  • Informed consent obtained from the patient or legal representative

Who cannot take part

  • Previous inclusion in the study
  • History of schizophrenia or bipolar disorder
  • Age >80 years
  • Moribund patients
  • Patients under legal guardianship
  • Pregnancy
  • No health insurance coverage
  • Refusal to participate

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 80 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

To evaluate the value of biomarkers of neuronal and glial injury for predicting cognitive impairment (memory impairment assessed by a MoCA score < 26/30) at 3 months in patient admitted in the intensive care unit for a sepsis or a septic shock.

Treatments tested

  • Serum

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Fit questions
Built from NCT07746050, who can take part
Record updated
4 August 2026