Tests one dose of ayahuasca in adults with non-epileptic seizures
Tests a single dose of ayahuasca in adults with psychogenic non-epileptic seizures.
Plain-language title generated from the registry record
Registry title: Effects of a Sigle Dose of Ayahuasca in Patients With Psychogenic Non-epileptic Seizures: an Open Label Clinical Trial
Key facts
- Where
- Ribeirão Preto, BrazilSee the site
- Phase
- Phase 1/2
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 60 with psychogenic non-epileptic seizures (PNES) who do not also have epilepsy. Everyone gets one dose of ayahuasca.
- Age
- 18 to 60 years
- Sex
- All sexes can join.
- Disease stage
- PNES confirmed by video-EEG monitoring (VEEG), no epilepsy as well, and at least one psychogenic seizure in the last 3 months. People are followed at outpatient clinics.
- Earlier treatment
- People must slowly reduce and stop any psychotropic medicines they take (antidepressants, antipsychotics, benzodiazepines, mood stabilizers or anticonvulsants). People who have used ayahuasca before cannot join.
Main reasons for not taking part
- Epilepsy
- History of substance use disorder
- Schizophrenia or other psychotic disorders
- Pregnant or breastfeeding women
- Refusing to stop current psychotropic medicines or to sign the consent form
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT07747324, who can take part
Where in Brazil
- Ribeirão Preto Medical SchoolRibeirão Preto, BrazilTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Sao Paulo
- Trial code
- NCT07747324
- Record updated
- 5 August 2026
- Original description
Open label intervention with a single dose of ayahuasca in patients with psychogenic non-epileptic seizures (PNES)Read full original descriptionShow less
Effects of a Sigle Dose of Ayahuasca in Patients With Psychogenic Non-epileptic Seizures: an Open Label Clinical Trial
Open label intervention with a single dose of ayahuasca in patients with psychogenic non-epileptic seizures (PNES)
Inclusion: Patients aged 18 to 60 with documented PNES (confirmed via VEEG), without a diagnosis of comorbid epilepsy, and currently receiving follow-up care at outpatient clinics. To enroll in the study, patients must undergo a gradual reduction and discontinuation of any psychotropic medications (antidepressants, antipsychotics, benzodiazepines, or mood stabilizers/anticonvulsants) they are currently taking, in order to avoid drug interactions with-or influence on-the effects of ayahuasca.
Exclusion: Patients who have not experienced psychogenic seizures in the last 3 months; patients diagnosed with epilepsy; patients who refuse to reduce or discontinue their current psychotropic medications; patients with a history of prior ayahuasca use; patients with a history of substance use disorder; patients who refuse to sign the Informed Consent Form; patients with schizophrenia or other psychotic disorders and/or impaired reality testing; and pregnant or breastfeeding women.