Two Anesthetic Gas Approaches and Time to Breathing Tube Removal in Weight-Loss Surgery
Compares two anesthetic gas plans on waking time in adults having bariatric surgery.
Plain-language title generated from the registry record
Registry title: Swap Anesthetic Versus Continuous Desflurane in Adults Undergoing Bariatric Surgery
Key facts
- Where
- Santiago, ChileSee the site
- Phase
- Phase 4
Where in Chile
- Clínica DávilaSantiago, ChileNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Clínica Dávila
- Trial code
- NCT07748247
- Record updated
- 5 August 2026
- Original description
This randomized, parallel-group, non-inferiority clinical trial aims to evaluate whether an anesthetic swap strategy consisting of sevoflurane followed by desflurane 30 minutes before the end of surgery is non-inferior to continuous desflurane anesthesia with respect to extubation time in adults undergoing elective laparoscopic bariatric surgery. Secondary outcomes include time to achieve a Patient State Index (PSi) greater than 80, time to achieve an Aldrete score of at least 8, incidence of postoperative nausea and vomiting, post-anesthesia care unit length of stay, and desflurane-related costs.Read full original descriptionShow less
Desflurane Versus Sevoflurane-Desflurane Swap in Adults Undergoing Bariatric Surgery: A Randomized Non-Inferiority Trial on Extubation Time
This randomized, parallel-group, non-inferiority clinical trial aims to evaluate whether an anesthetic swap strategy consisting of sevoflurane followed by desflurane 30 minutes before the end of surgery is non-inferior to continuous desflurane anesthesia with respect to extubation time in adults undergoing elective laparoscopic bariatric surgery. Secondary outcomes include time to achieve a Patient State Index (PSi) greater than 80, time to achieve an Aldrete score of at least 8, incidence of postoperative nausea and vomiting, post-anesthesia care unit length of stay, and desflurane-related costs.
Inclusion: Age 18 years or older; Scheduled for elective laparoscopic gastric bypass surgery; Body mass index between 30 and 50 kg/m²; American Society of Anesthesiologists physical status II or III; Able and willing to provide written informed consent.
Exclusion: Surgical procedure lasting less than 2 hours; Active illicit drug use or substance dependence; Significant cardiac disease; Moderate or severe obstructive respiratory disease, including uncontrolled asthma or chronic obstructive pulmonary disease; Known allergy or contraindication to medications used during the intraoperative period; Personal or family history of malignant hyperthermia; Advanced chronic kidney disease, defined as an estimated glomerular filtration rate below 60 mL/min; Myasthenia gravis or another neuromuscular junction disorder; Severe cognitive or psychiatric disorder; Body mass index greater than 50 kg/m²; Pregnancy or breastfeeding; Refusal to participate or withdrawal of informed consent at any time.