Hesperidin Supplement for Thinking Skills in Overweight Older Adults
Tests hesperidin for thinking skills in overweight or obese older adults.
Plain-language title generated from the registry record
Registry title: Cognitive Effects of Hesperidin in Overweight/Obese Older Adults
Key facts
- Where
- Shanghai, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for overweight or obese adults aged 55-75 years. It tests whether hesperidin, a citrus plant compound, helps thinking and memory.
- Age
- 55-75 years
- Sex
- Men and women can join.
- Disease stage
- Overweight or obesity: BMI of 24 kg/m² or more, or waist circumference of 90 cm (35 in) or more (men) or 85 cm (33 in) or more (women).
- Earlier treatment
- People who used weight-loss drugs or antidepressants (except statins) in recent months cannot join.
Main reasons for not taking part
- MMSE score below 20
- History of neurological disease such as Parkinson's, Alzheimer's or stroke
- Cancer, or severe liver, kidney or gut disease
- Strict vegetarians, binge eating disorder or heavy alcohol use
- Taking part in another intervention study
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 55 and 75 years old?
Source: NCT07750223, who can take part
Where in China
- Community Health Centers in ShanghaiShanghai, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Min Hou
- Trial code
- NCT07750223
- Record updated
- 6 August 2026
- Original description
A randomized, double-blind, placebo-controlled trial was designed to test whether two doses of hesperidin (a natural flavonoid from citrus fruits) improve cognitive function in overweight and obese older adults.Read full original descriptionShow less
A Randomized Controlled Trial of Hesperidin for Improving Cognitive Function in Overweight and Obese Middle-Aged and Older Adults
A randomized, double-blind, placebo-controlled trial was designed to test whether two doses of hesperidin (a natural flavonoid from citrus fruits) improve cognitive function in overweight and obese older adults.
A total of 105 participants, aged 55-75 years with a BMI ≥24 kg/m² or elevated waist circumference, will be randomly assigned to one of three 10-week treatments: placebo, low-dose hesperidin (300 mg/day), or high-dose hesperidin (600 mg/day).
The primary aim is to see if hesperidin supplementation enhances cognitive performance - specifically executive function, memory, and attention - and to explore any dose-response relationship.
Secondary aims include examining changes in gut microbiota composition and related metabolites, as well as exploring potential mechanisms behind any observed effects.
The findings are expected to provide scientific evidence on whether hesperidin could serve as a nutritional strategy to support cognitive health in this population.
Inclusion: Age 55-75 years; BMI ≥ 24 kg/m² or waist circumference ≥ 90 cm (men) / ≥ 85 cm (women); Willing to participate and sign informed consent.
Exclusion: Use of weight-loss drugs or antidepressants (except statins) within recent months; History of neurological diseases (Parkinson's, Alzheimer's, stroke, etc.); Malignant tumors, severe liver/kidney/gastrointestinal diseases; Strict vegetarians, binge eating disorder, heavy alcohol consumption; Other conditions judged by investigators as unsuitable; MMSE score < 20; Participation in other intervention studies.