Daily avocado eating and brain and heart health in people with prediabetes
Tests eating avocado every day for 12 weeks in people with prediabetes.
Plain-language title generated from the registry record
Registry title: Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals
Key facts
- Where
- Maastricht, NetherlandsSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 75 years old?
Source: NCT07752225, who can take part
Where in Netherlands
- Department of Nutrition and Movement SciencesMaastricht, NetherlandsNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Maastricht University Medical Center
- Trial code
- NCT07752225
- Record updated
- 27 August 2026
- Original description
Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with overweight or obesity. Secondary objective is to assess the effects of 12-week daily avocado consumption on brain insulin sensitivity after intranasal insulin delivery, vascular function, markers of metabolic health, cognition, and psychological well-being. For that purpose a total of 34 men and women between the ages of 40-75 years old, will participate in a randomised crossover intervention study.Read full original descriptionShow less
Effects of Long-term Avocado Consumption on Brain and Peripheral Cardiovascular Health in Pre-diabetic Individuals
Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with overweight or obesity. Secondary objective is to assess the effects of 12-week daily avocado consumption on brain insulin sensitivity after intranasal insulin delivery, vascular function, markers of metabolic health, cognition, and psychological well-being. For that purpose a total of 34 men and women between the ages of 40-75 years old, will participate in a randomised crossover intervention study.
Inclusion: Men and women, aged between 40-75 years; Pre-diabetes: (A1C of 5.7%-6.4%, a fasting plasma glucose (FPG) of 100-125 mg/dL, or a 2-hour oral glucose tolerance test (OGTT) result of 140-199 mg/dL); BMI ³ 25 kg/m2; Fasting serum total cholesterol < 8.0 mmol/L; Systolic blood pressure < 160 mmHg and diastolic blood pressure < 100 mmHg; Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study.
Exclusion: Abuse of drugs; Use of an investigational product within another biomedical intervention trial within the previous 1-month; Contra-indications for MRI imaging (e.g. pacemaker, surgical clips/material in body, metal splinter in eye, claustrophobia); Blood donation in the 8 weeks before the start of the study; Type 1 or type 2 diabetes; Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis; Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident; Fasting serum total cholesterol > 8.0 mmol/L; Use medication to treat blood pressure, lipid or glucose metabolism; Age less than 40 years old or older than 75 years; BMI < 25 kg/m2; habitual consumption of more than 1 avocado/ week; Left-handedness; Current smoker, or smoking cessation < 12 months; More than 3 alcoholic consumptions per day; Difficulties to draw blood.