NCT07754591Completed
Comparison of Dynamic Compliance and Airway Resistance in Pressure-Controlled Versus Volume-Controlled Ventilation in Children Undergoing Corrective Heart Surgery
Comparison of Dynamic Compliance and Airway Resistance in Pressure Versus Volume Controlled Ventilation Among Pediatric Patients With Left to Right Intra-Cardiac Shunt Undergoing Corrective Surgery
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
The goal of this clinical trial was to compare two settings on a breathing machine used during heart surgery in children. The children in this study were born with a hole inside the heart. The hole lets extra blood flow to the lungs. Over time this can make the lungs stiffer and harder to inflate. All the children had surgery to close the hole, using a heart-lung machine. During surgery, a machine breathes for the child. It can be set in two ways. One way controls the pressure of each breath. The other way controls the amount of air in each breath. The main questions it aimed to answer were: Which setting kept the lungs easier to inflate during and after surgery? Which setting made it easier for air to move through the breathing tubes? Researchers compared children who got pressure-controlled ventilation with children who got volume-controlled ventilation, to see if lung function differed between the two groups. Participants: Had surgery to close the hole in the heart Got one of the two breathing machine settings, chosen at random Had lung measurements taken at eight points, from just after the breathing tube was placed until they were ready to come off the machine.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 72 (actual)
- First submitted
- 4 Aug 2026
- Start date
- 13 Jul 2024
- Primary completion date
- 13 Jul 2025
- Lead sponsor
- Nilratan Sircar Medical College
- NCT number
- NCT07754591
What you commit to
- Study type: Interventional
- Participants enrolled: 72
- From 13 Jul 2024 to the primary completion date, 13 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of any other associated cardiac anomaly
- Allergy to milrinone
- Associated coagulation disorder
- Neurological disorder
- Failure to wean from cardiopulmonary bypass
Other
- Refusal to participate
- Sepsis
- Hepatic or renal dysfunction
Who the study is looking for
- Paediatric patients aged 1 month to 18 years
- Left-to-right intracardiac shunt lesions (atrial septal defect or ventricular septal defect) undergoing corrective surgery under cardiopulmonary bypass - Elevated pulmonary artery pressure: pulmonary artery systolic pressure 30 mmHg or above, and/or mean pulmonary artery pressure 20 mmHg or above
Age in the registry: 1 month to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nil Ratan Sircar Medical College and Hospital Coordinator of this site? Confirm its status | Kolkata | India | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.