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Lifestyle coaching to lower vascular risk for stroke, heart disease and dementia

Tests a lifestyle coaching program for people at risk of vascular disease.

Key facts

Who runs it
Andrew Appleton
Where
London, CanadaSee the site
Trial code
Registry title
The BASIC-S Feasibility Study for Vascular Risk Reduction
Status
Not yet recruiting
People taking part
120 people, planned
Started
1 Oct 2026
Expected to end
1 Oct 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • BASIC-S Intervention
  • Standard / Usual Care
Record updated
25 August 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 18 and older who work at or recently retired from London Health Sciences Centre or Western University, and their partners. It tests a lifestyle program to lower the risk of vascular disease.

Age
18 years and older
Sex
All sexes can join.

Main reasons for not taking part

  • Medical conditions that make light-to-moderate physical activity unsafe, unless a doctor clears it
  • Psychiatric hospital stay in the past 6 months, or changes to antipsychotic or mood-stabilizing medicine in the past 3 months
  • Severe memory or thinking problems that prevent giving consent or using study technology
  • Cannot read and understand English well enough to consent and complete the study

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

  • Adults aged 18 years and older currently employed at or recently retired from the London Health Sciences Centre (LHSC) or Western University (with an operational focus on pre-retirees aged 50 years and older)
  • The primary applicant (not their partner, if applicable) must be within two years before or after their retirement date
  • Spouse or cohabitating partner of an enrolled primary participant. Cohabitating partners may include a common-law partner, adult child, close friend, or roommate who lives with the primary participant and shares common health goals. Enrollment of partners is optional but strongly encouraged
  • Capable of providing informed consent
  • Has access to a mobile device capable of receiving Short Message Service (SMS) communications and viewing Portable Document Format (PDF) documents
  • Physically able to safely engage in light-to-moderate intensity physical activity

Who cannot take part

  • Active or unstable psychiatric illness, defined as hospitalization for psychiatric care within the preceding 6 months or modifications to antipsychotic or mood-stabilizing pharmacotherapy within the preceding 3 months. Participants with stable, medically managed psychiatric conditions remain eligible
  • Severe cognitive impairment that compromises the ability to provide informed consent or independently use study-related technology
  • Medical conditions that preclude safe participation in physical activity (for instance, unstable angina, uncontrolled arrhythmia, severe heart failure) without physician clearance
  • Inability to read and understand English sufficiently to provide informed consent and complete study procedures

Where in Canada

  • London Health Sciences Centre (LHSC)London, CanadaContact: Andrew J Appleton, MD. (principal investigator)No longer taking part

About the trial

What the trial wants to find out

Vascular risk factors drive stroke, heart disease, and dementia, but translating lifestyle guidelines into routine clinical care remains challenging. To address this, we developed BASIC-S (Blood Pressure, Activity, Sleep, Interaction, Consumption, and Support), a framework targeting Blood pressure, Activity, Sleep, Interaction (socially), Consumption (nutrition), and Support using partner support and motivational interviewing. This individual-focused approach bypasses the logistical and financial barriers of complex clinical interventions by using sustained behavioral science to support gradual lifestyle changes. This study is a single-center, mixed-methods, cluster-randomized pilot trial evaluating the feasibility of the BASIC-S protocol in an occupational setting. A maximum of 60 households (120 participants) will be randomized 1:1 to either the BASIC-S intervention (motivational coaching, secure video check-ins, automated text messages, and a digital workbook) or standard care. Outcomes will assess feasibility, acceptability, and the validity of new tracking metrics to inform a future full-scale trial.

The 2 groups in the trial

  • BASIC-S Intervention GroupTreatment being tested

    Households allocated to this arm receive a multicomponent behavioral lifestyle program grounded in the Information-Motivation-Behavioral Skills (IMB) model.

    Treatment: BASIC-S Intervention

  • Standard Care (Usual Care) GroupExisting treatment, for comparison

    Households allocated to this arm receive pure usual care to serve as a real-world comparator, continuing their routine healthcare and access to institutional wellness resources.

    Treatment: Standard / Usual Care

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Piloting an Integrated Lifestyle Intervention for Vascular Risk Reduction: The BASIC-S Feasibility Study
Plain-language title
Lifestyle coaching to lower vascular risk for stroke, heart disease and dementiaGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 13 November 2026.
Record updated
25 August 2026