Tests stroke volume guided fluid treatment in acute pancreatitis patients
Tests fluid dosing guided by stroke volume in adults hospitalized with acute pancreatitis.
Plain-language title generated from the registry record
Registry title: Stroke Volume-based Fluid Resuscitation in AP
Key facts
- Where
- Columbus and Los Angeles, United StatesSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07756476, who can take part
Where in United States
- Ohio State UniversityColumbus, United StatesNo longer taking part
- University of Southern CaliforniaLos Angeles, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Southern California
- Trial code
- NCT07756476
- Record updated
- 10 August 2026
- Original description
The SUSTAIN Trial is a randomized control trial that allows for the control of aggressive hydration that is currently used in an inpatient setting, which can result is fluid overload in certain patients. With the impression that changes in stroke volume in individual patient will further improve the outcome.Read full original descriptionShow less
Stroke volUme-baSed Fluid resusciTAtIoN in AP (SUSTAIN)
The SUSTAIN Trial is a randomized control trial that allows for the control of aggressive hydration that is currently used in an inpatient setting, which can result is fluid overload in certain patients. With the impression that changes in stroke volume in individual patient will further improve the outcome.
Inclusion: Patients between the age of 18-75; Predicted moderate and severe acute pancreatitis, which will be defined by the presence of SIRs, within 24 hours of enrollment.
Exclusion: NYHA Class >= II Heart Failure; Ages <18 years old; Patients with the inability to preform a straight leg raise (i.e amputation); Patients with high risk of adverse event related to fluid resuscitation; Child's B and C Cirrhosis; Dialysis Requirement; Clinical signs of hypervolemia, including pulmonary congestion (i.e dyspnea, pulmonary crackles on exam, interstitual edema on imaging) and ascites; Pregnant; Incarcerated; Unable to provide informed consent.