Polygonatum sibiricum herb for belly fat in adults with visceral obesity
Tests Polygonatum sibiricum plus lifestyle advice in adults with visceral obesity.
Plain-language title generated from the registry record
Registry title: Polygonatum Sibiricum Reduces Visceral Fat in Obese Adults
Key facts
- Where
- Hangzhou, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07759323, who can take part
Where in China
- Zhejiang Provincial Tongde HospitalHangzhou, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Zhejiang Provincial Tongde Hospital
- Trial code
- NCT07759323
- Record updated
- 12 August 2026
- Original description
This study is being done to find out if a traditional Chinese herb called Polygonatum sibiricum (Huangjing) can help reduce belly fat and improve metabolic health in adults with visceral obesity.Read full original descriptionShow less
Polygonatum Sibiricum for Visceral Obesity and Related Metabolic Abnormalities: A Randomized Controlled Trial and Mechanistic Exploration
This study is being done to find out if a traditional Chinese herb called Polygonatum sibiricum (Huangjing) can help reduce belly fat and improve metabolic health in adults with visceral obesity.
Visceral obesity means having too much fat stored deep inside the belly, around the organs. This type of fat is linked to a higher risk of diabetes, fatty liver, and heart disease.
The study will include 66 adults with visceral obesity. Participants will be randomly assigned to one of two groups:
One group will receive a Polygonatum sibiricum decoction (15 grams daily) plus standard lifestyle advice on diet and exercise.
The other group will receive the same lifestyle advice only.
The study will last for 12 weeks. Researchers will measure changes in visceral fat area, body weight, waist size, blood sugar, blood lipids, and liver fat. They will also look at gut bacteria and related markers to better understand how Polygonatum sibiricum might work.
Participation involves 4 visits to the study site over the 12-week period. All participants will receive free health assessments and dietitian guidance. The study is not a treatment but a research study to test whether this herb has potential benefits for visceral obesity.
Inclusion: Age 18 to 65 years, male or female; Body mass index (BMI) ≥ 24 kg/m², or body fat percentage ≥ 25% for males or ≥ 30% for females, and visceral fat area ≥ 100 cm²; Body weight stable within the past 3 months, with fluctuation not exceeding 5%; Able to understand the study content, voluntarily sign the informed consent form, and willing to complete follow-up visits and required examinations as scheduled.
Exclusion: Previous metabolic surgery or current use of weight-loss medications; Concomitant severe hyperglycemia or lipid metabolism disorders requiring immediate intensive treatment; Concomitant severe cardiovascular or cerebrovascular disease, or unstable medical condition; Allergy to or intolerance of any component of the investigational product; Secondary obesity (e.g., caused by endocrine disorders such as hypothyroidism, Cushing's syndrome, or polycystic ovary syndrome); Malignant tumors, active infections, or autoimmune diseases; Any other conditions deemed unsuitable for participation in this study by the investigator; Significant hepatic or renal dysfunction (e.g., ALT or AST > 2-3 times the upper limit of normal, or eGFR < 60 ml/min/1.73 m²); Use of antibiotics, probiotics, or other agents that may affect gut microbiota within the past month; Pregnancy, lactation, or plans for pregnancy.