Two endoscopic removal methods for small rectal neuroendocrine tumors compared
Compares two ways of removing small rectal neuroendocrine tumors during endoscopy in adults.
Plain-language title generated from the registry record
Registry title: Underwater Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Small Rectal Neuroendocrine Tumors
Key facts
- Where
- Guangzhou, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07759960, who can take part
Where in China
- Nanfang Hospital, Southern Medical UniversityGuangzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Nanfang Hospital, Southern Medical University
- Trial code
- NCT07759960
- Record updated
- 12 August 2026
- Original description
Underwater endoscopic mucosal resection (UEMR) and endoscopic submucosal dissection (ESD) have both been reported to be two effective treatment methods for small rectal neuroendocrine tumor (NET). However, there is no consensus on the best method for the endoscopic resection of rectal NET. Therefore, we aimed to compare the efficacy and safety of UEMR and ESD for the treatment of small rectal NET.Read full original descriptionShow less
Underwater Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Small Rectal Neuroendocrine Tumors: A Prospective, Multicenter, Non-inferiority Trial
Underwater endoscopic mucosal resection (UEMR) and endoscopic submucosal dissection (ESD) have both been reported to be two effective treatment methods for small rectal neuroendocrine tumor (NET). However, there is no consensus on the best method for the endoscopic resection of rectal NET. Therefore, we aimed to compare the efficacy and safety of UEMR and ESD for the treatment of small rectal NET.
Inclusion: Age from 18 to 75 years; With a high suspicion or evidence of rectal NET assessed using EUS, CT scan or colonoscopy; With tumor size ≤10 mm assessed by colonoscopy or EUS; Plan to receive UEMR or ESD treatment and provide written informed consent.
Exclusion: Received resection of rectal neuroendocrine tumor by other surgical procedures; Complicated with serious diseases such as malignant tumor, which may lead to shorter life expectancy, the research team considers that it is not suitable for inclusion in the study after comprehensive evaluation; Vulnerable groups such as pregnant women or patients with mental disorders; Unable to tolerate ESD or UEMR as assessed by the research team; Rectal NET with lymph node metastasis or distant metastasis; Multiple rectal neuroendocrine tumors; Poor compliance, unable to cooperate with treatment.