Comparing Two Ways to Take a Biopsy of Small Lung Nodules
Compares a needle biopsy through the skin with a robotic bronchoscope biopsy.
Plain-language title generated from the registry record
Registry title: A Randomized Controlled Trial Comparing Percutaneous CT-Guided Biopsy and Shape-Sensing Robotic-Assisted Bronchoscopy
Key facts
- Where
- Heidelberg, GermanySee the site
- Phase
- Phase 4
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who need a biopsy of a small lung nodule, 2 cm (0.8 in) or smaller. It compares two biopsy methods.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- A lung nodule of 2 cm or less in largest diameter, where a diagnostic biopsy is advised by the care team.
- Earlier treatment
- The nodule must not have been biopsied before by any method.
Main reasons for not taking part
- Earlier biopsy of the same nodule
- Was randomized in this study before but did not have the biopsy
- Pregnant or breastfeeding
- Cannot give informed consent for themselves, or is a vulnerable patient
- Taking part in another research study that could interfere with this one
Read by machine on 9 November 2026.
Where in Germany
- Thoraxklinik HeidelbergHeidelberg, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Intuitive Surgical
- Trial code
- NCT07761351
- Record updated
- 25 September 2026
- Original description
The ENCOMPASS study is a post-market, multicenter, randomized controlled trial comparing two established approaches for obtaining a biopsy of small pulmonary nodules (≤2 cm): CT-guided percutaneous lung nodule biopsy and shape-sensing robotic-assisted bronchoscopy with cone-beam CT (ssRAB with CBCT).Read full original descriptionShow less
A Randomized Controlled Trial Evaluating Lung Nodules - COMparing Percutaneous CT-Guided Biopsy And Shape-Sensing Robotic-Assisted Bronchoscopy (ENCOMPASS)
The ENCOMPASS study is a post-market, multicenter, randomized controlled trial comparing two established approaches for obtaining a biopsy of small pulmonary nodules (≤2 cm): CT-guided percutaneous lung nodule biopsy and shape-sensing robotic-assisted bronchoscopy with cone-beam CT (ssRAB with CBCT).
Inclusion: Patient is aged 18 years or older at time of consent; Diagnostic nodule biopsy(s) indicated per multidisciplinary team (or equivalent); Target pulmonary nodule ≤2 cm in largest diameter; Patient is willing and able to give written informed consent for clinical study participation.
Exclusion: Patient has previously undergone a biopsy procedure of the target nodule by any approach; Patient was previously randomized in this study but did not undergo biopsy; Patient is participating in an interventional research study or research study with investigational agents with an unknown safety profile that would interfere with participation in this study or study results; Patient is pregnant or breastfeeding as determined by standard site practices; Patient lacks the capacity to provide informed consent for themselves, or is a vulnerable patient whose ability to protect their own interests or to consent freely may be diminished, including but not limited to, patients who may be unduly influenced through dependency on the sponsor, the hospital, or the study doctor; Patient is not willing to comply with study participation requirements.