Classifying Types of Chronic Pain in People With Multiple Sclerosis
Identifies chronic pain types in adults with multiple sclerosis and compares their clinical features.
Plain-language title generated from the registry record
Registry title: Pain Phenotypes in Individuals With Multiple Sclerosis
Key facts
- Where
- Kütahya, TürkiyeSee the site
Where in Türkiye
- Kutahya Health Sciences University Physical Medicine and Rehabilitation DepartmentKütahya, TürkiyeTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Kutahya Health Sciences University
- Trial code
- NCT07766213
- Record updated
- 6 November 2026
- Original description
This observational cross-sectional study aims to determine chronic pain phenotypes in individuals with multiple sclerosis (MS) and to investigate the clinical characteristics associated with different pain phenotypes. Participants with MS and chronic pain will undergo a comprehensive clinical assessment to identify nociceptive, neuropathic, nociplastic, and mixed pain phenotypes. The assessment will include clinical history, pain characteristics and distribution, quantitative sensory testing, pain intensity, disease severity, fatigue, health-related quality of life, and pain catastrophizing. The clinical characteristics of participants with different pain phenotypes will subsequently be compared.Read full original descriptionShow less
Pain Phenotyping in Multiple Sclerosis Based on IASP Criteria
This observational cross-sectional study aims to determine chronic pain phenotypes in individuals with multiple sclerosis (MS) and to investigate the clinical characteristics associated with different pain phenotypes. Participants with MS and chronic pain will undergo a comprehensive clinical assessment to identify nociceptive, neuropathic, nociplastic, and mixed pain phenotypes. The assessment will include clinical history, pain characteristics and distribution, quantitative sensory testing, pain intensity, disease severity, fatigue, health-related quality of life, and pain catastrophizing. The clinical characteristics of participants with different pain phenotypes will subsequently be compared.
Inclusion: Age 18 years or older; Definite diagnosis of multiple sclerosis according to the McDonald criteria; No MS relapse or high-dose steroid treatment within the previous 3 months; Pain intensity ≥2 on the Numeric Rating Scale in at least one body region for at least 3 months; Ability to read, understand, and communicate in Turkish.
Exclusion: Severe psychiatric disorder and/or severe cognitive impairment confirmed by a neurologist or neuropsychiatrist; Presence of a serious pathology or disease that may compromise the assessment process or affect clinical decision-making, including metastasis, cancer, untreated or unhealed fractures, neurological disorders other than multiple sclerosis, or a history of diabetes; Pregnancy.