Planning heart bypass surgery with a CT scan instead of an invasive angiogram
Compares two ways of planning bypass surgery in adults with coronary artery disease.
Plain-language title generated from the registry record
Registry title: CCTA-Based vs CAG-Based CABG: A Multicenter Pragmatic Non-Inferiority Trial
Key facts
- Where
- Shanghai, ChinaSee the site
Where in China
- Ruijin Hospital, Shanghai Jiao Tong University School of MedicineShanghai, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Ruijin Hospital
- Trial code
- NCT07769008
- Record updated
- 27 October 2026
- Original description
The goal of this clinical trial is to find out if using a non-invasive heart scan (called coronary computed tomography angiography, or CCTA) to plan coronary artery bypass grafting (CABG) works as well as the standard invasive approach (called coronary angiography, or CAG) for people with blocked heart arteries.Read full original descriptionShow less
Coronary Computed Tomography Angiography-Based Versus Coronary Angiography-Based Coronary Artery Bypass Grafting: A Multicenter Pragmatic Non-Inferiority Randomized Controlled Trial
The goal of this clinical trial is to find out if using a non-invasive heart scan (called coronary computed tomography angiography, or CCTA) to plan coronary artery bypass grafting (CABG) works as well as the standard invasive approach (called coronary angiography, or CAG) for people with blocked heart arteries.
The main questions it aims to answer are:
Do people who have surgery planned with the non-invasive heart scan have similar health outcomes at 1 year as those who have surgery planned with the standard invasive approach? How does the non-invasive approach compare in terms of heart attacks, strokes, unplanned repeat procedures, and longer hospital stays? Researchers will compare two groups of participants. One group will have their surgery planned using only the CCTA . The other group will have their surgery planned using only the CAG. Both groups will undergo the CABG per local protocol.
Participants will:
Be randomly assigned (like flipping a coin) to one of the two planning approaches Undergo CABG as scheduled Return for follow-up visits at sugery days, 7 days, 1 month, 6 months, and 1 year after surgery Have a follow-up CCTA scan at 7 days and 1 year to check if the new bypass grafts are working well
Inclusion: Referred to CABG treatment.
Exclusion: Prior PCI with coronary stent implantation and unable to undergo photon counting CCTA; Concurrent participation in another interventional trial; Unable to undergo CAG or CCTA examination or deemed unsuitable by the investigator, such as:; Known allergy to iodinated contrast media; Active hyperthyroidism or uncontrolled thyroid disease; Estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m²; Atrial fibrillation with rapid ventricular response or severe arrhythmias not amenable to rate control; Under the age of 18 years; Unable to provide informed consent; Emergency CABG; Redo-CABG; Cardiogenic shock; Pregnancy, lactation, or childbearing potential without effective contraception in female participants.