Tests low-dose heart radiation in advanced heart failure
Tests low-dose radiation to the heart in adults with advanced heart failure.
Plain-language title generated from the registry record
Registry title: RADIATE-HF - Efficacy and Safety of Cardiac Radiation in Advanced Heart Failure
Key facts
- Where
- Rennes, FranceSee the site
Where in France
- Rennes University HospitalRennes, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Rennes University Hospital
- Trial code
- NCT07770230
- Record updated
- 11 September 2026
- Original description
The RADIATE-HF study is a prospective, interventional, single-center, open-label, non-randomized study conducted at the Rennes University Hospital.Read full original descriptionShow less
RADIATE-HF - Efficacy and Safety of Cardiac Radiation in Advanced Heart Failure: an Exploratory Single-Arm Study
The RADIATE-HF study is a prospective, interventional, single-center, open-label, non-randomized study conducted at the Rennes University Hospital.
The goal of this proof-of-concept trial is to demonstrate that low-dose cardiac radiation therapy (5 Gy) improves left ventricular function by more than 5% in the medium term in patients with advanced or end-stage heart failure.
The primary endpoint is the difference between the baseline value and the 6-month value of the LVEF as assessed by cardiac MRI.
The study includes a single group of 20 patients receiving the intervention (cardiac radiation).
The study is being conducted at a single investigator site.
Inclusion: Minimum age: 18 years; Ischaemic or non-ischaemic cardiomyopathies; Optimal medical treatment; LVEF ≤ 40%; NYHA class II or III; Life expectancy > 6 months; At least one hospital admission for heart failure within the 6 months prior to inclusion, or NT-pro BNP ≥ 1,000 pg/mL; Contraindications to heart transplantation and left ventricular or biventricular assist devices; Having given their free and informed written consent; Covered by a health insurance scheme.
Exclusion: History of thoracic radiotherapy; History of aortic and mitral valve surgery; Pregnancy or breastfeeding; Contraindications to MRI (claustrophobia, presence of metallic foreign bodies); Participation in another ongoing interventional study; Adults subject to legal protection measures (judicial protection, guardianship, curatorship), deprived of their liberty, or unable to give informed consent.