Efficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis
Key facts
- Who runs it
- Cairo University
- Where
- Egypt1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Not yet recruiting
- People taking part
- 40 people, planned
- Started
- 21 Aug 2026
- Expected to end
- 30 Nov 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- AI-Guided Physical Therapy Program
- Traditional Physical Therapy Program
- Lifestyle Modification and Joint Protection Education
- Record updated
- 19 August 2026
Who can take part
- Age
- 45 years to 70 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Participants will be recruited through outpatient orthopedic clinics and community health centers affiliated with the study sites
- Their age will be ranged from 45-70 years
- Their body mass index (BMI) will be ranged from 24.9 to 30 kg /m2
- With a clinical and radiographic diagnosis of knee osteoarthritis based on American College of Rheumatology criteria, with Kellgren-Lawrence grade II or III osteoarthritis, and who will able to ambulate
- Independently walk without assistive devices
Who cannot take part
- Prior knee replacement surgery, inflammatory arthritis (e.g., rheumatoid arthritis)
- Recent intra-articular steroid injections within three months
- Neurologic impairments affecting lower limb function
- Inability to comprehend or use the mobile application due to cognitive or sensory impairments
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 70 years old?
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This study aims to compare the effectiveness of an artificial intelligence (AI)-guided physical therapy program with a traditional physical therapy program in patients with knee osteoarthritis.
Read full original descriptionShow less
Forty patients with knee osteoarthritis will be randomly assigned to one of two groups. The traditional physical therapy group will receive a conventional rehabilitation program including transcutaneous electrical nerve stimulation (TENS), strengthening, flexibility, and balance exercises. The AI-guided group will receive an individualized rehabilitation program generated using ChatGPT-4 based on standardized patient information and clinical assessment findings.
Both groups will receive education regarding lifestyle modification and joint protection strategies. The effects of the two rehabilitation approaches will be evaluated by measuring pain intensity, knee range of motion, knee-related functional ability, and functional mobility and fall risk before and after the intervention.
The study will determine whether an AI-guided physical therapy program can provide outcomes comparable or superior to those of traditional physical therapy in individuals with knee osteoarthritis.
The 2 groups in the trial
- AI-Guided Physical Therapy Program + Lifestyle modification and joint protection strategiesTreatment being tested
Participants in this arm will receive an individualized AI-guided physical therapy program generated using ChatGPT-4. The researcher will manually enter standardized patient data, including age, sex, pain intensity (VAS), functional disability (WOMAC), knee range of motion, symptom duration, and physical activity level. ChatGPT-4 will then generate an evidence-based, in-clinic rehabilitation program for knee osteoarthritis. Participants will also receive education on lifestyle modification and joint protection strategies.
Treatment: AI-Guided Physical Therapy Program and Lifestyle Modification and Joint Protection Education
- Traditional Physical Therapy Program + Lifestyle modification and joint protection strategiesExisting treatment, for comparison
Participants in this arm will receive a conventional physical therapy program consisting of transcutaneous electrical nerve stimulation (TENS), strengthening exercises, flexibility exercises, and balance exercises. The program will be delivered three times per week for 12 weeks. Participants will also receive education on lifestyle modification and joint protection strategies.
Treatment: Traditional Physical Therapy Program and Lifestyle Modification and Joint Protection Education
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Fit questions
- Built from NCT07774195, who can take part
- Record updated
- 19 August 2026