Oral galactose to refill muscle energy stores after exercise in type 1 diabetes
Tests whether swallowed galactose is taken up by muscle in adults with type 1 diabetes.
Plain-language title generated from the registry record
Registry title: Oral Galactose as a Substrate for Post-Exercise Skeletal Muscle Glycogen Repletion in Individuals With Type 1 Diabetes
Key facts
- Where
- Aarhus, DenmarkSee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for healthy adults or adults with type 1 diabetes to test whether galactose taken by mouth is absorbed by muscle and heart during and after exercise.
- Age
- 20 to 70 years
- Sex
- All sexes can join.
- Disease stage
- Type 1 diabetes, or no diabetes (healthy volunteers).
- Earlier treatment
- No blood donation in the last 3 months. No other study with ionizing radiation in the last 6 months.
Main reasons for not taking part
- Significant heart, lung, kidney, liver, endocrine or cancer disease
- Not noticing low blood sugar (hypoglycemia) episodes
- Smoking
- Alcohol or substance abuse
- Claustrophobia, or not able to train one leg for one hour
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 70 years old?
Source: NCT07774780, who can take part
Where in Denmark
- Aarhus UniversitetAarhus, DenmarkNo longer taking part
- steno diabetes center AarhusAarhus, DenmarkNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Aarhus
- Trial code
- NCT07774780
- Record updated
- 19 August 2026
- Original description
This Ph.D. project investigates whether orally ingested galactose can be taken up by skeletal muscle and the heart in response to exercise or hyperinsulinemia, and whether it may serve as a viable nutritional strategy for individuals with type 1 diabetes (T1D).Read full original descriptionShow less
Oral Galactose as a Substrate for Post-Exercise Skeletal Muscle Glycogen Repletion in Individuals With Type 1 Diabetes
This Ph.D. project investigates whether orally ingested galactose can be taken up by skeletal muscle and the heart in response to exercise or hyperinsulinemia, and whether it may serve as a viable nutritional strategy for individuals with type 1 diabetes (T1D).
Although exercise provides significant health benefits for people with T1D, it is often associated with substantial glucose fluctuations and an increased risk of hypoglycemia. Conventional carbohydrate strategies based on glucose may further exacerbate glycemic instability due to the rapid increase in blood glucose levels. In contrast, galactose is metabolized more slowly and may therefore provide a more stable energy source during and after exercise.
Previous research has demonstrated that intravenously administered galactose is taken up by human skeletal muscle, with uptake increasing during exercise, suggesting a mechanism that may be at least partly insulin-independent. Building on these findings, this project aims to determine whether similar uptake occurs when galactose is ingested orally.
This study uses a randomized controlled design and applies non-invasive 18F-FDGal PET imaging to quantify galactose uptake in skeletal muscle and cardiac tissue. The findings may contribute to improving dietary recommendations for individuals with T1D, particularly in relation to maintaining stable blood glucose levels during and after physical activity.
Inclusion: Healthy or T1D; BMI 18,5-30 kg/m2; Singed informed consent.
Exclusion: Participation in other studies involving ionizing radiation within the last 6 months; Clinically significant heart, lung, kidney, liver, endocrine, or malignant disease based on information collected during the initial screening visit as well as blood tests; Lack of awareness of hypoglycemia episodes; Blood donation within the last 3 months; Smoking; Alcohol or substance abuse; Claustrophobia; Inability to train one leg for one hour.