Red grape juice and body chemistry in men with coronary artery disease
Tests daily red grape juice in men with chronic coronary artery disease.
Plain-language title generated from the registry record
Registry title: Study Evaluating the Effects of Red Grape Juice Consumption on Metabolism in Men With Coronary Artery Disease
Key facts
- Where
- São Paulo, BrazilSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 46 and 69 years old?
Source: NCT07777341, who can take part
Where in Brazil
- Incor - Instituto do Coração HCFMUSPSão Paulo, BrazilTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Sao Paulo General Hospital
- Trial code
- NCT07777341
- Record updated
- 28 August 2026
- Original description
Previous studies suggest that both RW and red grape juice (RGJ) have beneficial properties upon risk factors and cardiovascular events. However, the effects of grape polyphenols on metabolomics in men are still poorly understood. Recent advances in mass spectroscopy allowed substantial advances in the analysis of molecular signatures of several diseases.Read full original descriptionShow less
Effects of Red Grape Juice on the Plasma Metabolome in Chronic Coronary Artery Disease.
Previous studies suggest that both RW and red grape juice (RGJ) have beneficial properties upon risk factors and cardiovascular events. However, the effects of grape polyphenols on metabolomics in men are still poorly understood. Recent advances in mass spectroscopy allowed substantial advances in the analysis of molecular signatures of several diseases.
Therefore, the objective of this study is to evaluate the impact of RGJ on plasma metabolomics in patients with chronic coronary disease (CAD). This is a crossover, prospective, randomized and controlled study, with two 3-week interventions: 1. daily consumption of RGJ (400 mL) and 2. total abstention from foods rich in polyphenols. Plasma metabolomics will be performed by gas chromatography (GC)/mass spectroscopy (MS) by (Prof. Labate, Department of Plant Genetics, ESALQ). The sample will consist of 50 patients with chronic CAD. aged between 46 and 69 years. The inclusion and exclusion criteria were defined to achieve homogeneity of the group and avoid interference. The central hypothesis of this study is that RGJ will exert effects upon pathways involved in lipids, carbohidrates and energy production, contributing to the understanding of the mechanisms of action of polyphenols on cardiovascular health, without the risks associated with alcohol.
Inclusion: Age between 46 and 69 years; Established chronic coronary artery disease, defined by at least one of the following:; Acute myocardial infarction occurring more than 30 days before enrollment; Angiographic evidence of ≥50% stenosis in one or more epicardial coronary arteries; Previous percutaneous coronary intervention (PCI); Previous coronary artery bypass grafting (CABG); BMI <30 kg/m²; Absence of:; Angina symptoms; Dyspnea.
Exclusion: Use of antibiotics within 8 weeks before study enrollment; Use of antidiabetic medications; Use of illicit drugs; Heart failure, NYHA functional class ≥ II; Hepatic insufficiency, defined by:; Cancer; Inflammatory bowel disease; Obstructive biliary disease; History of digestive tract surgery, including:; Diabetes mellitus; Unstable angina; Moderate valvular heart disease; Chagas disease; Chronic obstructive pulmonary disease (COPD); Renal insufficiency, defined as creatinine clearance <30 mL/min, calculated using the Cockcroft-Gault equation; Reduced serum albumin; Thrombocytopenia; Prolonged prothrombin time; Cholecystectomy; Gastrectomy; Colectomy; Hypertriglyceridemia; Habitual consumption of wine or other alcoholic beverages; Permanent pacemaker implantation; Aortic aneurysm; Aortic ectasia measuring <40 mm.