Comparing Two Radiation Treatment Areas for Poorly Differentiated and Anaplastic Thyroid Cancer
Compares focused radiation with wider radiation in adults with aggressive thyroid cancer.
Plain-language title generated from the registry record
Registry title: Selective Coverage Versus Comprehensive Coverage Radiotherapy in Poorly Differentiated and Anaplastic Thyroid Cancer
Key facts
- Where
- Shanghai, ChinaSee the site
- Phase
- Phase 2
Where in China
- Fudan Universtiy Shanghai Cancer CenterShanghai, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fudan University
- Trial code
- NCT07777536
- Record updated
- 20 August 2026
- Original description
To explore the efficacy and safety of selective coverage radiotherapy in poorly differentiated and anaplastic thyroid cancerRead full original descriptionShow less
Selective Coverage Versus Comprehensive Coverage Radiotherapy in Poorly Differentiated and Anaplastic Thyroid Cancer: A Randomized, Controlled, Non-inferiority, Phase 2 Study
To explore the efficacy and safety of selective coverage radiotherapy in poorly differentiated and anaplastic thyroid cancer
Inclusion: Age ≥ 18 years old; Pathologically confirmed as ATC, thyroid cancer containing ATC components, PDTC (in accordance with Turin criteria), or other thyroid cancers with poorly differentiated components, and the MDT considers the biological behavior similar to PDTC; Evaluated by the MDT and proposed to receive external beam radiotherapy, including postoperative R0/R1, R2 gross residual, inoperable local lesion, and local recurrence; ECOG performance status 0-2; expected survival ≥ 3 months; major organ functions can meet the requirements for radiotherapy and the proposed systemic treatment; The subject voluntarily participates in the study and signs a written informed consent form, willing to follow up according to the protocol and fill in the quality of life scale.
Exclusion: Has received radiotherapy to the head and neck or upper mediastinum region in the past, and the target area of this study overlaps significantly with it, and the normal tissue limit cannot be met; Has severe uncontrolled infections, active bleeding, unaddressed airway crises, severe dysfunction of the heart, lungs, liver, kidneys or other diseases that cannot be safely treated with radiotherapy; Cannot complete radiotherapy fixation, simulation positioning or follow-up imaging assessment; Has other active malignant tumors within 5 years or simultaneously (excluding cured localized tumors such as skin basal cell carcinoma, skin squamous cell carcinoma, superficial bladder cancer, prostate carcinoma in situ, cervical carcinoma in situ, breast carcinoma in situ, etc.); Pregnant or lactating women; women of childbearing age who do not agree to take effective contraceptive measures; Other situations that the researcher deems unsuitable for participation in this study.